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How does estrogen therapy work?
Reduces bone loss and increases bone density by inhibiting osteoclast activity
AE of estrogen
Increased risk for endometrial cancer
If you give a person estrogen and progestin what are their risks?
- Increased risk for
- Cardiovascular disease
- Breast Cancer
- Uterine Cancer
How does Evista work?
Prevents bone loss by mimicking estrogen effects on bone density
AE for Evista
- Hot flashes
- Leg Cramps
- Blood clots
How do Biphosphonates work?
Inhibit bone resorption, so increases total bone mass
AE for Biphosphonates
Patient teaching for Biphosphonates
- Take with a full glass of water
- Take 30 min before food or other meds
- Remain upright for 30 min. after taking
How does Reclast work?
Prevents osteoporosis for 2 years after a single infusion
AE for Reclast
Flu symptoms for the first few days following administration
What kind of med is Reclast?
How does Miacalcin work?
It is Calcitonin and is normally secreted by the thyroid gland.....inhibits osteoclast resorption and inhibits renal calcium excretion
AE for Miacalcin
Intranasal-dryness and irritation
Im/Subq-nausea and facial flushing
How can Biphosphonates be given?
How can Miacalcin be given?
Intranasal or IM/Subq
What the name of the med that is given Subq every 6 months?
Example of Calcium supplements PO
- Calcium Chloride
- Calcium gluconate
What do calcium supplements help with?
maintenance of normal musculoskeletal, neurological and cardiovascular function
Calcium supplements by age
- 65 + = 1500mg
Optimal intake before age 30-35 increases peak bone mass
- elevated BP to brady to hypotension
- Abd pain
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