ClinMedV Toxicology (NSAIDS)

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Author:
heather.dundas
ID:
238598
Filename:
ClinMedV Toxicology (NSAIDS)
Updated:
2013-10-03 16:37:17
Tags:
vti
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vti
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  1. Brand name for acetaminophin:
    Tylenol
  2. Who has a low tolerance for acetaminophen where 1 dose can kill?
    cats
  3. What can happen to dogs with acetaminophen?
    less sever than cats, but liver damage or failure at toxic doses
  4. Toxic dose of acetaminophen in the dog.
    160-600mg/kg
  5. Toxic dose of acetaminophen in the cat.
    50-60mg/kg
  6. Clinical signs of acetaminophen are seen within 1-2 hours. What are they?ADVDCB/MDF
    • anorexia
    • depression
    • v+
    • dypsnea
    • cyanosis
    • brown mm/ methemogobinemia
    • dark urine
    • facial edema
  7. When is death seen for acetaminophen toxicity?
    1-2d
  8. Cats can't biotransform acetaminophen because of reduced ability to conjugate....
    glucuronic acid
  9. dx of acetaminophen toxicity
    based on hx and evidence of liver failure
  10. tx acetaminophen toxicity:EGSAA
    • emesis
    • GI decontamination
    • supportive care
    • acetylcysteine
    • ascorbic acid
  11. Acetylcysteine is a what stimulator?
    glutathione
  12. what does acetylcysteine do?
    acts as alternative substrate for conjugation and detoxification of acetaminophin
  13. In general NSAIDS have what effect?
    liver and kidney side effects
  14. dx of nsaid tox
    • hx
    • bw
  15. Name some GI protectants used to to treat NSAID tox:SC
    • sucralfate
    • cimetidine

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