What is the name for the varying regions and constant regions in the V region of an antigen, and how are they related to its secondary structure? Is there an alternate (more appropriate) name for the varying regions?
- There are three hypervariable regions (HV1, HV2, HV3) surrounded by framework regions (FR1, FR2, FR3, FR4)
- The framework regions form the β sheets (structure framework)
- The hypervariable regions form the outer edge of the β barrels (point of contact for antigens) and are termed complementarity-determining regions (CDRs) (CDR1, CDR2, CDR3)