In CVA how does up-regulation of Ach receptors occur? What effect does this have on succ and NDMR?
Ach receptors are spread over a large portion of the affected muscle. Many more ion channels open after administration of such, so this causes increased K+ levels. Sensitivity to succ.
Also, there is resistance to NDMR- related to spread of receptor sites in the extra junctional area. Extrajunctional receptors bind NDMR poorly.