Ipratropium Bromide

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What type is Ipratropium Bromide?

Anticholinergic bronchodilator
What is the action of Ipratropium Bromide?
- Bronchodilation
- Blocks vagal reflexes which mediate bronchoconstriction
- synergistic when used in combination with salbutamol.
What is the route for Ipratropium Bromide?

Nebulised
What is the onset for Ipratropium Bromide?

3-5 minutes.
What is the duration of Ipratropium Bromide?

2-4 hours
What is the use for Ipratropium Bromide?
- Moderate to severe asthma
- COPD
What are the adverse effects of Ipratropium Bromide?

Mild anticholinergic effects, e.g. urine retention.
What are the contraindications for Ipratropium Bromide?
- Allergy or hypersensitivity to Ipratropium Bromide
- Glaucoma.
What is the preparation for Ipratropium Bromide?
- 500mcg in 1ml nebule for pts. ≥6 yrs. of age
- 250mcg in 1ml nebule for pts. <6 yrs. of age
What is the dose of Ipratropium Bromide for moderate to severe asthma and COPD?
- Patients 6years of age or over
- 500mcg (1ml) nebulised mixed with salbutamol
- Repeat once whilst indicated
- Maximum dose: 1mg (2mL)
- Patients under 6 years of age
- 250mcg (1ml) nebulised mixed with salbutamol
- Repeat once while indicated
- Maximum dose: 500mcg (2mL)