Microcirculation and Lymphatic System
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What is the transport of nutrients to the tissues and the removal of cell exreta?
Arteries branch several times to be come ___.
Arterioles supply the _____.
_____ are larger than arterioles but weaker.
What is the thin slit curving channel that lies in between the endothelial cells that allows for the transport of substances?
The intercellular cleft space is smaller than the diameter of ____.
What part of the capillary membrane plays a role in endocytosis and transcytosis?
Plasmalemmal vesicle (calveolae - small caves)
- -vesicles can move slowly thru the cell
- -can make a channel that resembles a cleft
The junctions in the brain allow what kind of molecules thru?
- extremely small molecules
- such as H20, O2, CO@
The pores of the liver allow what kind of substances to pass thru?
- almost all dissolved substances of plasma including plasma proteins can pass into the liver
- -endothelial cells are wide open!
How does blood flow through the capillaries?
it does not flow continuously. flows as needed, every few secs to mins.
What is the flow of blood thru capillaries called?
Vasomotion ---> intermittent contractions to allow blood to flow thru as needed.
What regulates vasomotion?
Oxygen concentration in tissues
- *controls the flow of blood in the capillaries...
- when there is decreased tissue O2, intermittent flow in the capillaries occurs more frequently to supply blood to tissues
What is the most important means by which a substance is transferred?
How do lipid soluble substances get thru the cell membrane? What are some examples of this?
- -diffuse directly thru without having to go thru the pores
- -O2 and CO2
- -can permeate all areas so rate of transport is higher than lipid insoluble substances
What is it called when capillaries force fluid and dissolved substances through the capillary pores into the interstitial spaces??
What is it called when plasma proteins cause fluid movement by osmosis from the interstitial spaces into the blood?
What are the 4 primary forces that determine whether fluid will move in or out of the blood? These are called the Starling Forces.
- 1. Capillary Pressure (Pc)
- 2. Interstitial Pressure (Pif)
- 3. Plasma Colloid Pressure (TTp)
- 4. Interstitial Fluid Osmotic Pressure (TTif)
Capillary pressure forces ____.
How does fluid move with interstitial pressures?
- -if the pressure is positive--- the fluid will move inward.
- -if the pressure is negative--- the fluid will move outward.
Plasma colloid pressure causes ______.
causes osmosis of fluid inward.
Interstitial fluid osmotic pressure causes ____.
causes osmosis of fluid outward.
The sum of the 4 Starling Forces = ?
Net Filtration Pressure
capillary hydrostatic pressure
interstitial hydrostatic pressure
plasma oncotic (colloid) pressure
TTi or TTif =
interstitial fluid osmotic pressure
What is the Starling Equation?
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