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Chronic obstructive pulmonary disease persistent airflow limitation that is usually progressive and associated with chronic inflammatory response in airways and lungs to noxious particles or gases.
Which two diseases together make up COPD?
emphysemachronic bronchitis[treated mostly the same]
List risk factors for COPD.
SMOKINGoccupational dusts, chemicalsair pollutiongenetic predispositionairway hyperresponsivenessimpaired lung growth
T/F: all smokers will eventually get COPD.
- About 15-20% of smokers get COPD, but smoking is the leading cause of COPD.
Explain the pathophysiology of emphysema.
- macrophages/neutrophils --> elastase destroys elastin --> loss of alveolar integrity --> airway obstruction and collapse --> air trapping
- [bad gas exchange]
Explain the pathophysiology of chronic bronchitis.
- goblet cells hyperplasia/loss of cilia --> inflammatory thickening, excess mucous production -->mucous stagnation/plug --> obstruction and chronic infection
- [inflammation and mucous]
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