lung cancer

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Author:
alvo2234
ID:
240037
Filename:
lung cancer
Updated:
2013-10-11 15:12:55
Tags:
Dr Hunter
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Description:
PT IV Exam
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  1. histologic subtypes of non small cell lung cancer
    • squamous
    • adenocarcinoma
    • large cell
  2. sites of metastatic disease
    • brain
    • bone
    • liver
    • adrenal gland
  3. what does wet mean
    pleural or pericardial effusion
  4. when can cetuximab not be used
    K-ras mutation
  5. what are the poor prognostic factors
    • poor PS (ECOG 3-4)
    • activation of k-ras
    • mutation in p53
  6. when is surgery indicated for cancer pts
    stage I-IIIA are considered surgical candidates
  7. what is the gold standard for surgery
    sleeve lobectomy
  8. what are contraindications for surgery
    • poor performance
    • compromised cardiovascular function
    • poor pulmonary function
  9. what is anastomosis
    a surgical connection between two structures
  10. what is neoadjuvant mean
    intervention before chemotherapy
  11. what is the recommended drug regimen for resectable cancer pts
    • cisplatin 50 mg/m2 days 1 and 8
    • vinorelbine 25 mg/m2 days 1, 8, 15, 22
  12. what is the recommended tx for unresectable  stage IIIB cancer pts
    • chemotherapy along with radiation:
    • Cisplatin 50 mg/mg2 day 1, 8, 29, 36
    • Etoposide 50 mg/mg2 day 1-5, 29-33

    • followed by chemo alone:
    • docetaxel 75 mg/m2 q 21 days x 3 doses
  13. after unresectable pts have been treated with chemotherapy and/or radiation, what is the next step ?
    re-evaluate pts for surgical resection
  14. what is the second option treatment for unresectable cancer pts
    • cisplatin 100 mg/m2 days 1, 29
    • vinblastine 5 mg/m2 weekly x 5
  15. recommended platinum doublet tx for pts staged IV and IIIB (wet)
    • cisplatin 100 mg/m2 day 1 and
    • gemcitabine 1000mg/m2 day 1, 8, 15, q 4 wks
  16. which agent is used for cancer pts with mesothelioma
    pemetrexed
  17. in which cancer pts does cisplatin/pemetrexed show superiority in NSCLC
    • pts who do not have squamous:
    • adenocarcinoma
    • large cell
  18. where does bevacizumab target
    VEGF - vascular endothelial growth factor
  19. bevacizumab
    avastin
  20. what is bevacizumab
    humanized monoclonal antibody (93 - 95% human)
  21. tarceva
    erlotinib
  22. what is Erlotinib and when is it used
    it is a small molecule inhibitor (works inside cell) and it is used in pts with EGFR mutation (k-ras)
  23. what is the second line option used in cancer pts for relapse/progressive disease
    topotecan
  24. what is the median amt of treatment for unresectable cancer pts
    4  cycles

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