CYP2A6 are found in the liver, lungs and nasal epithelium. They metabolize drugs like coumarin, procarcinogens, and nicotine. These enzymes are known to have polymorphism. CYP2C is composed of CYP2C8 that is found in the liver and skin, CYP2C9 that is found primarily in the liver and intestine, and CYP2C19 that is primarily found in the liver and intestine. The CYP2C family metabolizes 25% of the clinically important drugs and represents 20% of the total CYP450 isozymes in the liver. They are also known to have polymorphisms. CYP2D6 have polymorphism and metabolize 21% of the clinically important drugs. They represents 3% of the total CYP450 isozymes in the liver. They do not appear to be inducible and their preferred substrates are lipophilic amines. CYP2E1 have minimal drugs that are metabolized by this CYP450 isoform. It is expressed in liver, kidney, intestine and lung. It is inducible by alcohol, diet, and diabetes. It also has a polymorphism in Chinese people.
- Where are CYP2A6 found?
- What doe CYP2A6 metabolize?
- Where is CYP2C8 found?
- Where is CYP2C9 found?
- Where is CYP2C19 found?
- What percentage of drugs does the CYP2C family metabolize?
- What is the preferred substrate for CYP2D6?
- Which cytochrome has a polymorphism in Chinese people?