Card Set Information
What is active immunization?
stimulation of immune response to
challenge w/ immunogen
How is active immunization crossed?
naturally through diease
admistered by health care worker
What is passive immunization?
What does passive immunization include?
IgG fraction from placenta of donors
How does passive immunization cross?
naturally across the placenta
In passive immunization was in injected?
serum containing Ab (antiserum)
What is the specific sera called in passive immunization?
What kind of protection is passive immunization?
rapid temp protection
When is passive immunization given?
post-exposure prophylaxis to
botulism, tetnusm diphtheria, Hep A&B, measles, and rabies
What else can can passive immunization be given for?
also done for snake and insect bites
What is the risk of passive immunization?
type III hypersensitivity rxn
Ag-Ab complexes cause activation of complement
natural exposure to Ag induces IR and now has immunity
deliberate exp to Ag induces IR
ex imms of children
trasnfer of Ab and gives temp immunity through the placenta/milk
Ab in immune serum are injected
rabies immune globulin given after dog bite
prep of microbe used to induce
artificial active immunity
What is Herd immunity?
immunity of critical portion of population (40%?)
How does herd immunity occur?
naturally or through vaccines
What is a vaccine composed of?
living or inactivated microbe
What cells do some vaccines involve?
What other kind of reponse can occur with vaccines?
some potentiate secondary humoral response
What are the tpyes of vaccines?
attenuated and inactivated
live but not pathogenic
What do attenuated vaccines do?
trigger cell-mediated response
gives her immunity (inffects nonvaccinated)
whole agent, subunit, both req boosters
no herd immunity
Types of viruses
What makes vaccines effective?
safe, long lasting, induces specific Abs/immune cells, low cost, stable, east to administer
What do attenuated (live) vaccines do?
results in undectable disease
long lasting immunity
cant cause disease
What are the vaccines that are attenuated (live)
MMR, oral Sabin polio, VZV, yellow fever
What are the negative affects of inactivated (killed) vaccines?
humoral, not cell-mediated
no local IgA response
req booster shots
What are the types of inactivated (killed) vaccines?
Examples of inactivated vaccines (killed)?
anthrax, cholera, salk polio, pertussis, rabies, influenza
Examples of inactivated vaccines (subunit)?
Examples of inactivated vaccines (kpeptide/poly)?
HiB, Pneumococcus, meningococcus, new HPV
Examples of inactivated vaccines (toxoid)?
How are inactivated (killed) vaccines given?
given with adjuvant
New vaccine for HPV?
women 9-26 y/o
What types of HPV serptypes?
6, 11, 16, 18
How is the
for the recombinant vaccine for HPV made?
protein subunits made by genetically-engineered microbe
When is HPV contraindicated?
persons allergic to yeast
What are there no vaccines for?
Malaria, influenza, syphilis, Strep, pyogenes, cold viruses, HIV, Herpes, Hep C