HSC303_CH6

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Author:
itzlinds
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240321
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HSC303_CH6
Updated:
2013-10-13 21:35:07
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Respiratory system
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respiratory system
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  1. select the option that is NOT true:

    Carbon dioxide is transported:

    A. dissolved in plasma
    B. as bicarbonate
    C. bound to white blood cells
    D. bound to hemoglobin
    C. bound to white blood cells
    (this multiple choice question has been scrambled)
  2. select the option that is NOT true:

    During exercise, there are higher requirement for oxygen delivery to the blood and carbon dioxide removal. This is acheived through:

    A. redistribution of blood flow
    B. increased capillary gas exchange at teh alveoli and muscle tissue
    C. decreased tidal volume coupled with increased ventilation frequency
    D. increased cardiac output
    C. decreased tidal voluume coupled with increased ventilation frequency
    (this multiple choice question has been scrambled)
  3. nasal passages and structures prior to the respiratory bronchioles:

    A. protect the alveoli from damage
    B. have cilia to move mucus into the alveoli
    C. engage in capillary
    D. are the primary sites where macrophages consume particles
    A. protect the alveoli from damage
    (this multiple choice question has been scrambled)
  4. select the option that is NOT true:

    airflows between the two areas of the ventilator pathway depends on:

    A. resistance to flow between the two areas
    B. the oxygen content of the blood
    C. pressure difference between the two areas
    D. the diameter of the airway
    B. the oxygen content of the blood
    (this multiple choice question has been scrambled)
  5. the peripheral chemoreceptors that help regulate ventilation:

    A. are located in the pons
    B. are especially responsive to carbon dioxide
    C. are located in the medulla
    D. are espcially sensitive to changes in the paritial pressure of oxygen
    B. are especially responsive to carbon dioxide
    (this multiple choice question has been scrambled)
  6. why is carbond dioxide able to diffuse across respiratory and cellular membranes with smaller partial pressure difference than oxygen?

    A. it requires an input of energy to transport the oxygen
    B. the membrane are more permeable to carbon dioxide than oxygen
    C. less oxygen diffuses across than carbon dioxide
    D. the parital pressure of carbon dioxide is much higher in the atmosphere than in the alveoli
    B. the membrane are more permeable to carbon dioxide than oxygen
    (this multiple choice question has been scrambled)
  7. at the end of exhalation:

    A. lung capacity increases
    B. exchange of gases continues at the alveoli
    C. the lungs collapse
    D. all air is removed from the lungs
    B. exchanges of gases continues at the alveoli
    (this multiple choice question has been scrambled)
  8. during transitition to exercise, the first ventilator response is to increase:

    A. tidal volume
    B. breathing from the mouth to the nose
    C. frequence of breathing
    D. lung capacity
    A. tidal volume
    (this multiple choice question has been scrambled)
  9. under normal conditions, ventilation is controlled:

    A. almost perfectly in relation to oxygen consumption
    B. primarily by the partial pressure of oxygen
    C. primarily by the partial pressure of carbon dioxide
    D. almost entirely by acidity
    C. primarily by the partial pressure of carbond dioxide
    (this multiple choice question has been scrambled)
  10. what is the primary fxn of the lungs:
    to exchange gases between the air and the blood
  11. list the structures of the respiratory system:
    • nose/nostrils
    • nasal cavity
    • pharynx, larynx, trachea
    • bronchi: 2 (one leading to each lung)
    • bronchioles
    • alveoli: sac like structures surrounded by capillaries where gas exchage takes place
  12. list and describe the 3 processes necessary  to protect the bronchioles and alveoli:
    • humidifying air: prevents the membranes from damage due to drying out or desiccation
    • warming the air: helps to maintain the temperature of teh lungs, and temp. of structures where gas exchange takes place
    • filtering the air: mucus traps airborne particles, cilia move mucus twoard oral cavity to be expelled
  13. what are the characteristics of alveoli:

    what are the 2 fxn/benefits of the alveoli:
    • characteristics
    • saclike structures surrounded by capillaries in lungs
    • attached to respiratory bronchioles
    • 300 million in the lungs

    • fxns/benefits
    • site of exchange of oxygen & carbon dioxide
    • provide tremendous surface area where diffusion can take place
  14. further aiding pulmonary diffusion are two cell membranes that compose the:

    where are the 2 membranes found:
    further aiding pulmonary diffusion are two membranes that compose the respiratory membranes

    • -the membrane of the alveolar cells
    • -the membrane of the cells of the capillary wall
  15. each lung is encased by a double layer _____ sac.

    list each layer, and what it surrounds:
    pleural sacs

    • visceral (pulmonary) pleura: surrounds outer surface of the lungs
    • parietal pleura: surrounds the inner surface of the throacic cavity & digaphragm
    • pleural fluid: lubriacting fluid bewteen the 2 membranes
    • intrapleural pressure: pressure in pleural cavity between 2 membranes; less atmosphereic pressure
  16. describe the changes during ventilaiton when there is an increase in volume of intrathoracic cavity:
    • an increase in lung volume
    • intrapulmonic pressure decreases
    • air rushes into the lungs (inspiration)
  17. describe the changes durin  ventilation when there is a decrease in volume of intrathoracic cavity:
    • a decrease in lung volume
    • the volume of the intrathoracic caivity increases
    • air rushes out of the lungs (expiration)
  18. the most important inspriatory muscle is the:

    explain how the contraction of this muscle affects volume and pressure:
    • -diaphragm is the most important inspiratory muscle
    • -as the diaphragm contracts, it flattens out, resulting in an increase in intrathroacic volume and putting into motion the intrathoracic pressure changes that cause inspiration

    contraction moves the abdominal contents foward & downward

    other accessory inspiratory muscles are: external intercostals, scalenes,  sternoclediomastoid, pectoralis minor
  19. at rest, no muscluar effort is needed to cause expiration, explain how the elastic properties of the diaphragm aid in expiration:
    upon relaxation of the diaphragm intrathoracic volume decreases and results in the motion of changes in intrapulmonic presssure that cause expiration
  20. list the muscles that aid voluntary, forced expiration during exercise:
    • internal intercostals
    • rectus abdominis
    • internal oblique muscles of abdominal wall

    - accessory muscles of expiration contract, pulling the ribs downward
  21. express the equation for the relationship bewteen pressure and resistance in regards to airflow

    what are the 3 main factors that affect airflow:

    what decreases reistance to airflow during exercise:


    • the pressure difference between the 2 areas
    • resistance to airflow
    • diameter of the airway

    bronchodilation decreases resistance to airflow during exercise
  22. the amount of air moved in and out of the lungs during a practicular timeframe (1 minute) is called:
    pulmonary ventilation
  23. the amount of air moved per breath is called:
    tidal volume
  24. what is the equation used to express pulmonary ventilation:
    VE= VT x f

    • VE= volume of air expired per minute
    • VT= tidal volume ( amount of air moved per breath)
    • f= frequency per minute

    -or-

    • VE= VA + VD
    • VA= anatomical dead space: air that never reaches the alveoli
    • VD= alveolar ventilation: air that does reach the alveoli
  25. describe how lung capacities and volume affect the mehanics of ventilation:
    • determied using spirometry equipment
    • reserve of tidal volume at rest allows tidal volume to increase during exercise
    • residula volume: the amount of air left in the lungs after max exhalation
    • residual volume is important bc it meas lungs do not empty or collapse, becuase air remains with the lungs.....ALLOWS FOR CONTINUEOUS EXCHANGE OF GASSES AT THE ALVEOLIE BETWEEN BREATHS
  26. describe how the frequency and depth of breathing affect the mehcanics of ventiliation:
    • -from rest to exercise, an increase in the depth of breathing (vT= tidal volume)
    • -if an increase in depth is not sufficent, an increase in breathing frequency will occur
  27. list the 2 factors that aid gas diffusion at the lungs/capillary:

    what is the driving force of gas diffusion:
    • the large surface area of the alveoli
    • thinness of the respiratory membrane (only 2 cells thick)

    driving force: the pressure difference of oxygen and cabon dioxide between air in the alveoli and the blood
  28. the driving pressure of oxygen and carbond dioxide between air in the alveoli and the blood is determined by which 3 concepts:
    • partial pressure: the portion of pressures due a particular gas in a mixture of gasses in both the blood and the alveoli
    • Dalton's law:
    • Henery's Law
  29. the total pressure of a gas mixture is equivalnet to teh sum of all the pressures of all the gases that compose the mixtures is stated as:
    Dalton's Law
  30. the law that states that the amount of gas dissolved  in any fluid depends on the temperature, partial pressures of gas, and the solubility of the gas is called:
    Henery's Law

    • temperature of blood is constant
    • solubility of oxygen and carbon dioxide wihin the blood is constant
    • the amount of gases dissolved in the blood is directly dependent on the partial pressure
  31. describe how oxygen diffusion into the blood is directed by Henery's Law:
    • Parital pressure of oxygen (PO2) must be greater alveoli than in the blood
    • Partial pressure of oxygen (PO2) must be greater in the blood than in the tissues

    the differences betwee PO2 in the alveoli & blood and between the blood and the tissue provide the driving force for diffusion of oxygen
  32. describe how carbon dioxide diffusion in the blood is directed by Henery's Law:
    • Partial pressure of carbon dioxide (PCO2) must be greater tissues than in the blood
    • Partial pressure of (PCO2) must be greater in the blood than the alveoli
    • Partial pressure of PCO2 must be greater in the alveoli than in the atmospheric air
    • **Expiration**

    differeces between PCO2 tissue & blood, and difffereces between PCO2 in blood & alveoli provide the driving force for diffusion of caron dioxide
  33. pulmonary blood flow deteremines the velocity at which blood passes thru the __________.

    as blood flow increases, as in during exercise, the more total ________ can take place.
    • pulmonary blood flow deteremines the velocity at which blood passes thru the pulmonary capillaries
    • as blood flow increases, as in during exercise, the more total gas diffusion can take place
    • BP in the pulmonary circulation is very low (25/10); this help to protect thin respiratory membrane from damgae due to high BP
    • increased capillary blood volume slows blood transit time thru capillaries; allows for more time for gas equilibration and maintain low BP
  34. describe the effiency of transporting oxygen carried in the blood to the body thru:

    plasma:
    RBC:
    • plasma: only 9 to 15 mL of oxygen can be dissoloved in plasma, which is insuffficent to meet the needs of the body
    • RBC: red blood cells containing hemoglobin ( an iron-containing pigment capable of reversibly binding to oxygen) transports 98% of oxygen
  35. when oxygen is bound to hemoglobin, _________ is formed.

    hemoglobin not bound to oxygen is termed:
    oxyhemoglobin

    deoxyhemoglobin

    becuase majority of oxygen is transported bound to hemoglobin, its concentration determins the amount of oxygen that can be transported by the blood
  36. the ability of hemoglobin to bind and release oxygen at correct site is explained by oxyhemoglobin disassociation curve:

    in the lungs, 100% saturation occurs, even if PO2 drops here, little change in oxygen saturation would occur, so the curve is flat, why is this physiologically important:
    ensures that close to 100% saturation takes place at the lungs even if PO2 at the lungs decrease due to factors suc as an assent to moderate altitude
  37. the ability of hemoglobin to bind and release oxygen at correct site is explained by oxyhemoglobin disassociation curve:

    the curve has a very steep slope, at the location of active tissues where PO2 is low, this ensures that a small change in PO2, a very large change in oxygen saturation will take place. why is this important:
    oxygen will be more readily released and available to the tissues, critical for supply of oxygen to tissues during exercise when PO2 at the tissue level decreases
  38. describe how an increase or decrease in temperature shifts the oxyhemoglobin curve:
    • -an increase in temperature shifts the curve to the right
    • -this means that an increase in temp. decreases affinity of hemoglobin for oxygen resulting in lower % oxygen saturation at any given PO2
    • -aids the delivery of oxygen to muscle tissue, more oxygen to muscle

    • -a decrease in temperature shifts the curve to the left
    • -a decrease in temp. increases the affinity of hemoglobin for oxygen
  39. describe how an increase or decrease in pH effect (Bohr effect) shifts the oxyhemoglobin curve:
    -an increse in pH shifts the curve to the right-an increase in pH decreases affinity of hemoglobin for oxygen (H+ increases and reversibly binds to hemoglobin) **same as temperature**aids in delivery of oxygen to tissues**

    • -a decrease in pH shifts the curve to the left
    • - a decrease in pH increases affinity of hemoglobin for oxygen
  40. describe how 2,3 Diphosphoglycerate (2,3 DPG), a byproduct of anaerobic rxns from glycolysis, shifts the oxyhemoglobine curve:
    • -an increase in 2,3 DPG shifts the curve to the right
    • - 2,3 DPG can loosely bind to hemoglobin reducing its affinity for oxygen, and increasing oxygen delivery to the tissue

    • - a decrease in 2,3 DPG shifts the curve to the left
    • -increases affinity of hemoglobin for oxygen
  41. list the 3 methods for carbon dioxide transport in the blood:
    • plasma: 7-10% dissoloved CO2
    • hemoglobin: 20% hemoglobin bound
    • bicarbonate: 70%
  42. gas exchange at the muscle or any tissue occurs due to:
    partial pressure differences between oxygen & carbon dioxide between tissue & blood
  43. an oxygen transport molecule similar to hemoglobin except that it is found within skeletal and cardiac muscle is called:
    myoglobin

    • -reversibly binds with oxygen from the cell membrane to the mitochondria
    • -assists in passive diffusion of oxygen from cell membrane to mitochondria (speeds up diffusion of oxygen)
    • -fnx as oxygen reserve at the start of exercise (oxygen bound to myglobin maintains O2 requirements of muscle that is becoming active, lag from ventilation)
  44. describe the characteristics of muscles fibers with myglobin:
    • high in Type I fibers
    • high aerobic capacity ( slowtwitch)
    • appears reddish
    • high mitochondria content
  45. how is the disassociation curves different for hemoglobin and myoglobin:
    • myoglobin has a much steeper curve
    • approches 100% oxygen saturation at a much lower PO2
    • within mitochondria active muscles, PO2 is low
    • allows myoglobin to transport oxygen at the lower levels of PO2 found within skeletal muscle
  46. which 2 structures of the brain make up the respiratory control center, serving as the "pacemaker":
    • medulla oblongata
    • pons
    • capable of generating a rhythmical breathing pattern
    • pulmonary ventilation is generally involuntary, but it can be changed voluntarily
  47. the rate & depth of breathing can be modified by:
    • higher brain centers
    • chemoreceptors in the medulla
    • other peripheral inputs
  48. chemoreceptors that respond to changes within the cerebral spinal fluid and are especially sensitive to changes of H+ concentration of pH are called:
    central chemoreceptors
  49. chemoreceptors located within the carotid arteries and the arotic arch that repsond to changes in blood PCO2 and H+ concentration  are called:
    peripheral chemorecptos

    • -carotid bodies also repsond to changes in PO2, montior changes within head/brain
    • aortic monitos pulmonayr/systemic circulation
  50. how do the lungs contribute neural imput for control of ventilation
    • the lungs contain stretch receptors, mainly in bronchioles
    • diaphragm/abdominal muscles contain stretch receports and sense metabolic changes
  51. how do the muscles contribute neural imput for control of ventiliation:
    proprioceptors (muscle spindles, golgi tendon bodies) are sensitive to changes in body position

    chemoreceptors are sensitive to potassium concentrations, and H+ concentration
  52. describe the 3 phase of submaximal exercise and pulmonary ventilation:
    • phase 1
    • -ventilation increase due to motor cortex activity and propoceptors in active muscles
    • -short plateau last 20 sec. tthen exponentially rise to reach steady-state leve

    • phase 2
    • -continued effect of motor cortex, feedback from active muscles, feedback from peripheral chemoreceptors
    • -steady-state level

    • phase 3
    • -fine-tuning of pulmonary ventilation during steady-state
    • -feedback from pheripheral chemoreceptors, central chemoreceptors so ventilation is matched to meet demands of submaximal exercise

    • exercise stops
    • -quick drop in ventilation
    • -removal of feedback from motor cortex, proprioceptors in active muscles
  53. the amount of air ventilated needed to obtain 1 L of oxygen or expire 1 L of carbon dioxide are called:
    ventialtory equivalents

    ventilatory equivalent of oxygen: ratio of pulmonary ventilation (VE) to oxygen (VO2): VE/VO2

    ventilatory equivalent of carbon dioxide: ratio of pulmonary ventilation (VE) to carbon dioxide (VCO2) VE/VCO2
  54. the technique of using ventilatory equivalents to estimate lactate threshold is called:
    ventilatory threshold
  55. the work intensity at which both VE/VO2 & VE/VCO2 increase is called:
    respiratory conpenstion point (RCP)

    • -characterized by a decrease in end-trial partial pressure of O2
    • -indicates end of control of VE by PCO2
  56. VT & RCP can be used to create 3 training zones of exercise intensity, based on heart rate:
    • light intesity: <VT
    • moderate-intensity: between VT & RCP
    • high intensity: >RCP

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