ACEI and ARB's
Card Set Information
ACEI and ARB's
Pharm Midterm Fall 2013
ACEI end in
ARB drugs end in
Indications for ACEI and ARB
prolong survival- should be given ACEI trial)
MI- prolong survival
prolongs survival rate( should be given ACEI trial)
block the conversion of angiotensin I to angiotensin II (this is very important)
Positive effects of ACEI on cardiac function
reduces preload and afterload
increases CI and EF=increased CO (increased blood to coronary arteries, and increased nourishment to the heart)
ACE increase blood flow to which vital organs
kidneys (without reflex tachycardia)
ACEI and ARB's are ______ protective
block the effect of angiotensin II by blocking angiotensin II to its receptor site.
Unlike ACEI, ARB's do not increase the level of ________?
ACEI increase the level of bradykinin, and ARB's do not.
Receptor affinity in ARB drugs
candesartan> ibesartan> eprosartan> telmisartan> valsartan> losartan
Does not always mean that candesartan should be started first, it has a lot to do with what the insurance company will pay for.
Dosage of ACEI and ARB's
vary with drug
usually given every day or twice per day
START LOW AND GO SLOW!!
ADR of ACEI and ARBs
Very rare and very few
Rare- rash, diaphoresis, flushing, photosensitivity, and puritis, abdominal pain, nausea, diarrhea, constipation, asthma, bronchospasm
COUGH- RARE WITH ARBS
Common ADR of ACEI
Cough and angioedema (potentially life threatening and is common with ACEI, greater than 50% of occurrences will occur within one week of therapy)
Do not use ______ in patient with renal artery stenosis because blood flow is diminished
ACEI- especially bilateral artery stenosis
ACEI are good for kidneys but not if they have renal stenosis
ACEI and ARBs are not as beneficial in _______ population
Use thiazide diuretic, and CCB
ACEI should be given to all patients with symptomatic or asymptomatic ________?
Monitoring ACEI and ARBs
All patients should have a periodic ______, ______, _______, and _________.
urinalysis, BUN, creatinine, and serum electrolytes.
Once dose is stable check creatinine and potassium after 2-4 weeks
Then if patient without risk factors can check them every 3-6 months.
ACEI and ARB pregnancy category
C and D