Anesth drugs

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Author:
desaix
ID:
240876
Filename:
Anesth drugs
Updated:
2013-10-24 20:41:57
Tags:
Drugs
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Description:
Drugs
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  1. Midazolam 2mg
    • Hepatic metabolism -> renal excretion
    • onset: 60 s
    • duration: 10-30 mins
    • induction dose: 0.05-0.15
    • sedation dose: 0.5-1 mg
  2. Propofol 150 mg
    • hepatic glucuronidation -> renal excretion
    • onset: 30 s
    • duration: 5-10 mins
    • induction dose: 1.5-2.5 mg/kg
    • sedation dose: 25-75 mg

    • -medium ideal for bacteria - discard after 6h
    • -venous irritation
    • -reduces PONV - anti-emetic
    • -allergies are rare - egg allergy?
  3. Ketamine IV
    • NMDA receptor antagonist
    • hepatic cyp3a4 -> renal excretion
    • onset - 45-60s
    • duration - 10-20 mins
    • induction dose: 0.5-2.0 mg/kg
    • sedation dose: 0.2-0.8 mg/kg (same for analgesia)

    • eyes open, increased muscle tone, myoclonus, analgesic, increased secretions, restlessness, agitation, nightmares for weeks
    • CI: ischemic HD, valvular disease, uncontrolled HTN, pre-eclampsia,
  4. Sevoflurane
    • MAC 2.0
    • Blood solubility 0.68
    • 5% absorbed 
    • pleasant odor, respiratory depression, bronchodilation, decreased BP, dec contractility, increase CBF (vasodilation)
    • metabolized by liver into compound A & B - compound A may cause renal toxicity (in mice)
    • dose-related proteinuria, glycosuria and enzymuria in humans
  5. Desflurane
    • MAC 6.0
    • Blood solubility 0.42
    • not metabolized
    • can be used for inhalation induction
    • airway irritability, breath holding, laryngospasm, salivation
    • increased levels release catecholamines increasing HR and BP
  6. Fentanyl
    • synthetic opioid agonist
    • 100x more potent than morphine
  7. Ephedrine
    • Indirectly releases endogenous catecholamines -> a & b activation -> inc HR, BP, CO
    • 5-10 mg boluses
  8. Fentanyl bottle
    • 50 mcg/mL
  9. Sux bottle
    • 20 mg/mL
  10. Roc bottle
    • 10 mg/mL
  11. lido bottle
    • 10 mg/mL
  12. propofol (diprovan)
    • 10 mg/mL
  13. dexamethasone (decadron)
    • 4 mg/mL
  14. ondansetron
    • 2 mg/mL
  15. ephedrine
    • 50 mg/mL
  16. phenylephrine
    • 10 mg/mL
  17. epi
    • 1 mg/mL
  18. dimenhydrinate
    • 50 mg/mL
  19. labetalol
    • 5 mg/mL
  20. morphine
    • 2 mg/mL

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