TOB Alimentary II (14)

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TOB Alimentary II (14)
2013-10-18 19:22:47
Tissue Organ Biology

Exam 3
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    • traditional lobule scheme of liver organization
    • traditional lobules divide the liver into many small, hexagonally shaped lobules
    • T = portal triad
    • V = central vein
    • hepatic acinus schemes of liver organization
    • has a central axis connecting 2 portal triads & extends outwards to 2 central veins
    • around the central axis the hepatocytes can be arranged into 3 concentric, elliptical zones defined metabolically and reflect a gradient in availability of oxygen and nutrients
    • more physiologically relevant model for the structure and function of the liver
  1. bile canaliculus
    • formed when one hepatocyte contacts another hepatocyte
    • these are involved in the exocrine functions of the liver: transport of bilirubin, bile salts & IgA to gall bladder & duodenum
  2. perisinusoidal space (space of Disse)
    • formed when one hepatocyte contacts a sinusoid
    • these are involved in microvilli formation and endocrine functions occur here (such as glycogen, lipid, & blood content regulation)
  3. What kind of exchange occurs between the blood plasma and the hepatocyte surface?
    essentially free exchange
    • Kupffer cells
    • liver macrophages that phagocytose particulates
    • they are attached to sinusoidal endothelial cells' luminal surface
    • gallbladder
    • distensible bag attached to underside of the liver that stores & concentrates bile
    • Rokitansky-¬≠Aschoff Sinuses
    • pockets in the wall of the gallbladder (entrapped epithelial crypts)
    • histologically, they are outpouchings of gallbladder mucosa into the gallbladder muscle layer and subserosal tissue