Fluids, Electrolytes, & Acid-Base Disorders
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What is contraction alkalosis?
GI losses deplete ECF volume causing a decrease in glomerular filtration rate --> increased aldosterone secretion --> increased HCO3- reabsorption = alkalosis
Correction depends on Cl- replacement (saline)
% of body weight that is water in:
Why do females have a smaller % body weight that is water?
Fat contains little water and females have more subcutaneous fat than males do.
Similarly lean individuals have greater proportion of body water than obese individuals and total body water decreases with age (as lean muscle mass decreases)
What is the % body weight that is water in infants?
Decreases to that of adults by 1yo.
Division of body water compartments:
Most intracellular water resides in:
Principal intracellular cations:
- Potassium (K+)
- Magnesium (Mg2+)
Principal intracellular anions:
Principal extracellular cation:
Principal extracellular anions:
- Chloride (Cl-)
- Bicarbonate (HCO3-)
Signs/Symptoms of hypophosphatemia:
- respiratory failure
- congestive heart failure
- metabolic acidosis
- sudden death
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