Cell Physiology & Structure

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    • Phospholipids in the cell membrane:
    • Phosphatidylcholine
    • Phosphatidylethanolamine
    • Phosphatidylinositol (PI)
    • Phosphatidylserine - negatively charged
    • sphingomyelin
  1. Function of phospholipids:
    • Structural component of cell membrane
    • PLA-arachidonic acid pathway
    • Phospholipase C (PLC) pathway
    • marking apoptotic cells for phagocytosis
    • Self-antigens in autoimmune disorders
  2. Phosphatidylinositol 3'kinase (PI3K)
    A lipid kinase that phosphorylates inositol phospholipids, derivatives of phosphatidylinositol, to transmit intracellular signals in response to growth factors and cytokines
  3. Arachidonic Acid Pathway
    Arachidonic acid cleaved from the two-position on membrane phospholipids by Phospholipase A to eventually form leukotrienes and prostaglandins
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Cell Physiology & Structure
Cell Physiology & Structure
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