Cell Physiology & Structure
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- Phospholipids in the cell membrane:
- Phosphatidylinositol (PI)
- Phosphatidylserine - negatively charged
Function of phospholipids:
- Structural component of cell membrane
- PLA-arachidonic acid pathway
- Phospholipase C (PLC) pathway
- marking apoptotic cells for phagocytosis
- Self-antigens in autoimmune disorders
Phosphatidylinositol 3'kinase (PI3K)
A lipid kinase that phosphorylates inositol phospholipids, derivatives of phosphatidylinositol, to transmit intracellular signals in response to growth factors and cytokines
Arachidonic Acid Pathway
Arachidonic acid cleaved from the two-position on membrane phospholipids by Phospholipase A to eventually form leukotrienes and prostaglandins
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