Hyperkalemia (binding to extra-junctional receptors in muscle -> transient K+ release -> possible death)
Phase II neuromuscular block
Why there are severe adverse effects of succinylcholine?
Succinylcholine binds to ACh receptors in teh ANS -> affecting both the sympathetic and asympathetic nervous output
Name 5 non-depolarizing NMBs.
Cis- Atracurium (Intermediate-acting)
Pharmacokinetics of Mivacurium
e.g. duration of action, onset, metabolism
Duration of Action: 5-10 mins (short-acting)
Onset: not rapid
Metabolism: esterase (which is abundant in body leading to rapid elimination and short duration of action)
Pharmacokinetics of Atracurium
e.g. duration of action, metabolism
Duration of Action: 20-30 mins (intermediate-acting)
Metabolism: Hofmann elimination (not enzymatic but depends on temperature and pH -> good for storage as in low temp and low pH there will be no metabolism) -> high confidence in retaining the motion power regardless of the liver function of the patient
most popular NMB
Why long-acting NMB is not preferred?
Giving Short-eacitng drugs continuously gives higher degree of flexibility