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Nutrigenetics
how an individual's genetic makeup influences utilization and response to dietary components.
Nutrigenomics
how dietary components affect expression of genetic information
Individual's with 2+ STAT3 polymorphisms resulted in a significantly greater increase in waist circumference when consuming SFA compared to those with < 2 STAT3 polymorphisms. (example of nutrigenetics or nutrigenomics?)
Nutrigenetics
Those with TCF7L2 polymorphism (mutant gene TT) decrease risk of stroke when following a MedDiet. (example of nutrigenetics or nutrigenomics?)
Nutrigenetics
A mutation in SLC01B1 (regulates hepatic uptake of drugs) results in increased plasma levels of statin drug and a side effect of myopathy. (example of nutrigenetics or nutrigenomics?)
Nutrigenetics
Following a MedDiet w/VOO (virgin olive oil) decreases gene expression changes (example of nutrigenetics or nutrigenomics?)
Nutrigenomics
Transcription Factors
Proteins that bind to specific sequences in DNA and promote or inhibit gene expression
PUFAs impact PPARs (Peroxisome Proliferator Activated Receptors) it will affect the gene which is responsible for increased lipogenesis resulting in a decrease in lipogenesis (example of nutrigenetics or nutrigenomics?)
Nutrigenomics
Epigenetics
gene regulation "above" the gene (DNA methylation)