for each deficiency what was done to over come it?
1. Acid stability->Penicillin V over comes this is acid stable issue with addition of oxygen, same spectrum of action, penicillin VK oral stable form
2. beta-lactimase sensitivity-> addition of a bulky group to to overcome beta lactimase activity...methacilllin, nafcillin, isoxazolyl panicillin, oxacillin... these are penicillinase- resistant penicillins Their ONLY PURPOSE is to Tx staphylococcus infections b/c they produce beta-lactimase
3.Not broad spectrum-> the addition of an amino group to create ampicillin and amoxicillin, allow for gram (-) pour passage and this makes it extended spectrum
4. Can't Tx pseudomonas-> production of anti-pseudomonal penicillins, Carboxypenicilins- tricacillin carbenicillin and Ureidopenicillins- piperacillin, aziocillin, meziocillin. Ureidopenicillins are derivatives of ampicillin therefore they extend the spectrum of apicillins .