- Aldosterone Receptor Blocker
- Spironolactone (Aldactone)- competitive inhibitors of aldosterone binding promotes retention of potassium and excretion of sodium/water.
Indication- weak diuretic and anti-HTN effect compared to other diuretics; may benefit pts with hx of MI, CHF
Side-effects/Nursing actions- diarrhea, GI upset, give after meals, teach signs of hyperkalemia, don't use K supplements o salt substitutes containing K; avoid grapefruit juice and St John's Wart; Gynecomastia may be cause by spironolactone; possible increase in triglycerides
Contraindications- hyperkalemia, impaired renal function