Pathology Images - Effect of Injury on Tissue II

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    • Fatty Change - Steatosis
    • Intracellular
    • 1) chronic- macrovesicular. trigylcerides, alcohol, reversible, nucleus off to side
    • 2) acute - microvesicular, fatty acids, drugs, irreversible, nucleus in middle

    Oil red O would be best stain to use
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    • Macrovesicular Fatty Change
    • Intracellular
    • chronic, nucleus pushed to periphery, triglycerides
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    • Microvesicular Fatty Change
    • Intracellular
    • Acute, multiple small droplets around central nuclei, fatty acids
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    • Glycogen Storage Disease
    • Intracellular
    • white space around nucleus (perinuclear)
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    • Mallory Bodies
    • Intracellular
    • Heat Shock Proteins + Intermediate Filaments

    Described as Hyalin, indicates cell damage
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    • Hemosiderosis
    • intraceulluar pigment accumulation - heme derived
    • macrophages containing hemosiderin = "Heart Failure Cells"
    • Stain golden brown
    • localized
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    • Hemosiderosis
    • intraceulluar pigment accumulation - heme derived
    • macrophages containing hemosiderin = "Heart Failure Cells"
    • Stain golden brown
    • systemic- from blood transfusions
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    • intraceulluar pigment accumulation - heme derived
    • regeneration nodule, primary, secondary
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    Hemosiderin, prussian blue, systemic
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    • bile accumulation in canaliculi
    • heme-derived intracellular
    • grossly, tissue would look yellow
    • jaundice
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    • Copper Accumulation
    • Non-heme derived pigment accumulation
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    • Melanin Accumulation
    • Intracellular, non-heme derived
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    • Amyloidosis
    • Interstitial Accumulation
    • Misfolded amyloids (amyloids are normally present)- beta pleated sheets. AA, AL
    • can use congo red to light it up
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    • Dystrophic Calcification
    • Interstitial Accumulation
    • High serum, normal tissue
    • localized, calcium stains dark purple
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    • Metastatic Calcification
    • Interstitial Accumulation
    • Normal Serum, Abnormal Tissue
    • all over, calcium stains dark purple
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242002
Card Set
Pathology Images - Effect of Injury on Tissue II
Description
Images for Effects of Injury on Tissue II
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