kinetics test 2

Card Set Information

Author:
coal
ID:
242500
Filename:
kinetics test 2
Updated:
2013-11-01 01:11:40
Tags:
kinetics test
Folders:

Description:
kinetics test 2
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user coal on FreezingBlue Flashcards. What would you like to do?


  1. cyclosporine t 1/2
    • adults no liver failure = 10
    • adults w/ liver failure = 20
    • children < 16 yo = 6
  2. cyclosporine Vd & F
    • 5L/Kg
    • 0.3
  3. which body weight do you use for cyclosporine
    all the normal body weight calculations
  4. how is cyclosporine dosed
    BID
  5. tacrolimus Vd & F
    • adults = 1L/Kg
    • < 16 yo = 2.6L/Kg
    • 0.25
  6. which body weight do you use for tacrolimus
    actual body weight
  7. tacrolimus t 1/2
    • adults no liver failure = 12
    • adults w/ liver failure = 60
    • children < 16 yo = 12
  8. what strengths does cyclosporine come in
    25 & 100 mg
  9. what strengths does tacrolimus come in
    0.5,1,5mg
  10. lithium Vd & F
    • 0.7L/kg
    • 1
  11. lithium t 1/2
    • adults = 24
    • 9-12 yo = 18
  12. which body weight do you use for lithium
    actual
  13. therapeutic range of carbamazapine
    4-12 mg/L
  14. which weight do you use for carbamazapine
    ideal body weight
  15. therapeutic range of phenytoin
    10-20 mg/L
  16. formula for adjusted concentration of phenytoin w/ altered albumin w/o renal failure
    measured total concentration/ [(0.2 x albumin) + 0.1]
  17. formula for adjusted concentration of phenytoin w/ altered albumin w/ renal failure (CrCl < 10 ml/min)
    measured total concentration / [(0.1 x albumin) + 0.1]
  18. therapeutic range of valproic acid
    50 - 100 mg/L
  19. Dose related adverse reactions of cyclosporine
    • hypertension
    • neurotoxicity
    • nephrotoxicity
  20. other adverse reactions of cyclosporine
    • nausea
    • gingival hyperplasia
    • hirsutism
    • opportunistic infections
    • malignancies
  21. what 3 meds could cause compounding nephrotoxicity with cyclosporine
    • NSAIDS
    • aminoglycosides
    • tacrolimus
  22. effects of food on cyclosporine
    increased fat in meals = increased absorption
  23. another name for tacrolimus
    FK506
  24. 4 dose related adverse effects of tacrolimus
    • nephrotoxocity
    • neurotoxicity
    • hypertension
    • post-transplant diabetes (20%)
  25. 4 other adverse reactions of tacrolimus
    • hyperkalemia
    • hypomagnesemia
    • myocardial hypertrophy
    • alopecia
  26. effects of antacids on tacrolimus
    decrease concentrations
  27. effects of food on tacrolimus
    decreases rate and extent of absorption
  28. affects of renal failure on cyclosporine and tacrolimus
    none
  29. lithium onset of action and complete therapeutic effect
    • 1-2 weeks
    • 4-6 weeks
  30. what effects on lithium for
    dehydration
    diuretics
    NSAIDs
    Theophylline
    • increase reabsorption
    • decrease clearance
    • decrease clearance
    • increase clearance
  31. typical starting dose of lithium
    900-2400 mg/day given TID
  32. black box warning for carbamazapine
    • serious dermatologic reactions
    •   HLA-B 1502 allele
    • aplastic anemia
    • agranulocytosis
  33. most common adverse effects from carbamazapine
    • CNS
    •   nystagmus
    •   ataxia
    •   blurred vision
    •   drowsiness

    teratogenic
  34. affect of uremic pts on carbamazapine
    significant increase in free concentrations
  35. what enzymes does carbamazepine induce
    • 1A2
    • 2C9
    • 3A4
  36. affects of carbamazepine on warfarin
    induces metabolism
  37. affects of carbamazepine on simvastatin
    greatly decreases concentration
  38. when is autoinduction usually assumed to be done with carbamazapine
    5-7 days
  39. how often do you increase the maintenance of carbamazapine
    1-2 week intervals
  40. long term side affects not related to plasma phenytoin concentrations
    • gingival hyperplasia
    • folate deficiency
    • peripheral neuropathy
  41. CNS side effects related to phenytoin levels
    • far lateral nystagmus > 20mg/L
    • ataxia & diminished mental capacity>30-40mg/L
  42. 3 factors that significantly alter the plasma protein binding of phenytoin
    • hypoalbunemia
    • renal failure
    • displacement of other drugs
  43. 3 suggestions for phenytoin dose increases based on Css levels
    • <7mg/L = 100mg/day
    • 7-<12 mg/L = 50mg/day
    • >12 mg/L
  44. what is the dose limiting affect for valproic acid
    GI - N/V, diarrhea, abdominal cramps
  45. what are elevated levels of valproic acid associated with
    hepatotoxicity
  46. what affect does food have on valproic acid
    slow the rate of absorption
  47. what happens when valproic acid levels exceed 50mg/L
    binding to albumin is saturated
  48. therapeutic range of digoxin for HF
    0.5-0.9 ng/ml
  49. therapeutic range of digoxin for Afib
    0.5-2.0 ng/ml
  50. bioavailability of digoxin dose forms
    • IV - 1
    • tablet - 0.7
    • elixir - 0.8
  51. explain the distribution of digoxin
    equate with cardiac and skeletal muscles but not so much in to adipose tissue
  52. average Vd of digoxin
    7 L/kg
  53. primary elimination route of valproic acid
    hepatic
  54. primary elimination route of digoxin
    renal - 70%
  55. average half life of digoxin
    1-2 days - 36 + 8 hrs
  56. loading doses of digoxin are useful for what state
    AFib
  57. what strengths does digoxin come in
    • tabs - 125,250
    • IV - 250 mcg/ml
    • elixir - 50 mcg/ml
  58. loading dose of digoxin
    • rapid = PO - 500mcg: 250mcg, wait 4-6 hrs, 125mcg, wait 4-6 hrs, 125 mcg
    • rapid = IV - 375 mcg: 125mcg wait 4-6 hrs, 125mcg, wait 4-6 hrs, 125 mcg
  59. what meds would you 1/2 the dose of digoxin in
    • quinidine
    • verapamil
    • amiodarone
  60. what would decrease Vd in digoxin
    • renal disease
    • hypothyroidism
    • quinidine
  61. what would increase Vd in digoxin
    hyperthyroidism
  62. what would decrease Cl in digoxin
    • hypothyroidism
    • amiodarone
    • quinidine
    • verapamil
  63. what would increase Cl in digoxin
    hyperthyroidism
  64. what would decrease toxicity in digoxin
    • hyperkalemia
    • hyperthyroidism
  65. what would increase toxicity in digoxin
    • hypocalemia
    • hypomagneseia
    • hypothyroidism
    • hypercalcemia
    • renal dysfunction
    • quinidine
    • amiodarone
    • verapamil
  66. affects of food on digoxin
    • decreased peak concentrations
    • meals containing high fiber or pectin may decrease oral absorption

What would you like to do?

Home > Flashcards > Print Preview