Pang Proteins

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Author:
lawlzcakes
ID:
242743
Filename:
Pang Proteins
Updated:
2013-10-27 15:04:02
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Robbiepoo
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Stupid stuff
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  1. INFLUX GUT CELL APICAL MEMBRANE
    ASBT, PEPT-1, MCT-1, OATP-2B1/1A2, NPT, NT-1/2, AAT, OCT-1
  2. EFFLUX GUT CELL APICAL MEMBRANE
    Pgp/MDR-1, MPR-2, BCRP
  3. INFLUX GUT CELL BLOOD MEMBRANE
    MCT-1
  4. EFFLUX GUT CELL BLOOD MEMBRANE
    MRP-3
  5. INFLUX LIVER CANALICULAR MEMBRANE
    None
  6. EFFLUX LIVER CANALICULAR MEMBRANE
    Pgp, MRP2, BSEP, MATE, BCRP
  7. INFLUX LIVER SINUSOIDAL MEMBRANE
    OATP-1B1/1B3/2B1, NTCP, OAT-2, OCT-1, MCT-2
  8. EFFLUX LIVER SINUSOIDAL MEMBRANE
    MRP-3
  9. INFLUX KIDNEY BRUSH BORDER MEMBRANE
    OCT-N1/N2, OATP 1A2, PEPT-1/2, ASBT, CNT-1/2, NT-1/2, Ascorbic acid Transporter, Inorganic Sulfate ion
  10. EFFLUX KIDNEY BRUSH BORDER MEMBRANE
    MRP-2/4, MATE, Pgp, BCRP, OATK-1/2
  11. INFLUX KIDNEY BASOLATERAL MEMBRANE
    OAT-1/2/3, OCT-1/2/3
  12. EFFLUX KIDNEY BASOLATERAL MEMBRANE
    MRP-3, OST-ALPHA/BETA
  13. ABCs = ?
    Pgp, BCRP, MPR-2, BSEP, MATE
  14. Brain Efflux
    P-gp, BCRP
  15. ASBT can transport what? (3 things)
    Taurocholate, Urso/Cheno-deoxycholic acid
  16. ASBT stands for
    Apical Sodium-dependent Bile acid Transporter
  17. PEPT-1 transports? (6 things/groups; 3 of which has e.g.)
    • -Penicillins
    • -Amino-cephalosporins
    • -ACE inhibitors (E.g. statins/bestatins)
    • -Peptidomemetic prodrugs (Antiviral nucleosides such as Acyclovir/Valacyclovir)
    • -Short-chain peptides
    • -Di/Tri-peptides (E.g. Beta-lactam antibiotics: Cepha-, Cefa-)
  18. PEPT1 stands for what? It is coupled with? Therefore it is affected by change in?
    • Oligopeptide Transporter 1
    • Proton Coupled therefore affected by pH
  19. MCT-1 transports? (1 group; 3 examples)
    Simple Carboxylic acids (Salicylic acid, benzoic acids, Gamma hydroxybutyrate (GHB))
  20. MCT-1 stands for?
    Monocarboxylic acid Transporter 1
  21. OATP stands for ? What types are there? What is it inhibited by ?
    • Organic Anion Transporting Polypeptide.
    • 1B1/1B3/1A2/2B1 types
    • Inhibited by grapefruit juice
  22. OATP 2B1/1A2 tranports what ?
    • Endogenous substrates (e.g. steroid conjugates E1S)
    • Xenobiotics (e.g. statins)

    Examples for above: Estrone sulfate, benzylpenicillin, pravastatin, glibenclamide
  23. OATP 1B1/1B3 transports what ?
    • Endogenous substrates: Taurocholate, bile acids, bilirubin
    • Anions: Estrogen sulfate, E217G, Ace inhibitors (enalapril[Vasotec], temocaprilat), HMG Co-A inhibitor (statins-pravastatin, rosuvastatin, atorvastatin), BSP, methotrexate, peptides
    • Steroids: Ouabain, thyroid hormones
    • Cations - fexofenadine (Allegra), ajmalinium, quaternary ammonium compounds (vercuronium, N-methylquinidine)
  24. NPT stands for ?
    Sodium-dependent Phosphate Transporter
  25. NPT looks for what molecules in a drug?
    P=O and ONa
  26. NPT transports ?
    • Fosfomycin (antibacterial)
    • Foscarnet (antiviral)
  27. Amino Acid Transporter transports ?
    • Gabapentin (seizures)
    • Baclofen (spasticity)
    • D-cycloserine (antibiotics)
    • L-dopa
    • Methyldopa
  28. OCT stands for ? And how many types ?
    Organic Cation Transporter 1/2/3
  29. OCT-1 in the GUT transports ?
    Antivirals (Acyclovir, ganciclovir)
  30. OCT-1 in LIVER transports ?
    • Procainamide ethylbromide (PAEB)
    • Tetramethylammonium (TEA)
  31. OCT-1/2/3 in KIDNEY transports what ?
    • Procaineamide ethylbromide
    • tetraethylammonium
    • cimetidine
    • choline
    • cisplatin,
    • corticosterone
    • desipramine
    • histamine
    • procainamide
    • quinidine
    • ritonavir,
    • saquinavir
    • verapamil
    • metformin
  32. NT stands for ? How many types are there?
    Nucleoside transporter 1/2/3/4/5
  33. NT-1 transports what? What do the drugs look like?
    Allopurinol and Azathiprine. Look like purines
  34. NT-2 transports what? What do the drugs look like?
    Gemcitabine, cytarabine and 5-Fluorouracil. Look like pyrimidines
  35. NT-1/2/3/4/5 in LIVER transports what?
    • Acyclovir
    • HIV inhibitors - AZT (Zidovudine), ddl, ddc, ribavirin
  36. MCT-2 stands for?
    Monocarboxylic acid transporter 2 and is a proton cotransporter
  37. MCT-2 transports?
    Bigger carboxylic acids like lactate, pyruvate and benzoate
  38. NTCP stands for?
    Sodium-dependent Taurocholate coTransporting polypeptide
  39. NTCP transports?
    • Bile Acids - Taurocholate (TCA), cholic acid, URSO
    • Statins - Pitavastatin, rosuvastatin, atorvastatin
    • Anions - Estrone 3-sulfate (E1S), E217G, Bromosulfophthalein (BSP)
  40. OAT stands for? How many types?
    Organic Anion Transporter 1/2/3
  41. OAT-2 transports?
    P-aminohippurate, NSAIDs, salicylate, cephalorsporins
  42. OAT-1/3 transports? And Uses what transport system and, in that system, with what compound? Inhibited by?
    Transports P-aminohippurate (PAH), Penicillins, Uric acid, probenecid, salicylic acid, acetylsalicyclic acid, indomethacin, prostaglandins, cephaloridine

    Uses tertiary transport system with alpha keotglutarate

    Inhibited by probenecid
  43. OCTN-1 transports?
    Electroneutral substrates: Beta-lactam antibiotics, cephaloridine, cefoselis, cefepime, cefluprenam
  44. OCTN-2 is a?
    Sodium-carnitine cotransporter
  45. Ascorbic acid transporter and inorganic sulfate ion transporter are dependent on?
    Na
  46. Pgp stands for? and is also known as? What does that one stand for?
    P-glycoprotein. AKA MDR1 - Multidrug resistance protein 1
  47. Pgp/MDR1 mostly transports drugs that are? (2 things)
    Lipophilic and anti-cancer
  48. Pgp/MDR1 transports?
    • ·        
    • Vinca Alkyloids (vinblastine, vincristine)

    • ·        
    • Anthracyclines (doxorubicin, daunorubicin)

    • ·        
    • Taxanes (Paclitaxel, docetaxel)

    • ·        
    • Epipodophyllotoxins (etoposide, teniposide)

    • ·        
    • Steroids (aldosterone, dexamethasone)

    • ·        
    • HIV Protease Inhibitors (Indivavir, saquinavir,
    • nelfinavir, ritonavir)

    • ·        
    • Cardiac glycosides (digoxin)

    • ·        
    • Peptides (leupeptin, pepstatin A)

    • ·        
    • Antihypertensives (propranolol, verapamil)

    • ·        
    • Others (cyclosporins, rhodamine 123)
  49. MRP-2 stands for?
    Multidrug resistance-associated protein 2
  50. MRP2 transports?
    • § 
    • Conjugates: Glucuronides, glutathione, and
    • sulfate

    • § 
    • Statins: Pravastatin and cerivastatin

    • § 
    • HIV protease inhibitors: Saqunavir, Ritonavir,
    • and Indinavir

    • § 
    • ACE inhibitors: enalapril and enalaprilat

    • § 
    • Others: Etoposide, benzylpencillin, vincristine
  51. BCRP stands for?
    Breast cancer resistance protein
  52. BCRP transports?
    • § 
    • Sulfate conjugates (E1S):
    • Phytoestrogens, flavonoids, cimetidine sulfate, conjugates of steroids (estrone
    • sulfate), 4-methylumbelliferone sulfate

    • § 
    • Anticancer drugs: Mitoxantrone, topotecan,
    • vinblastine, methotrexate, 9-aminocamptothecin, rubitecan, anthracyclines (-rubicins)
  53. BSEP stands for?
    Bile salt export pump
  54. BSEP transports?
    Bile acids, pravastatin, rosuvastatin
  55. MATE stands for?
    Multidrug and toxic compound extrusion
  56. MATE transports?
    • § 
    • Cationic dyes

    • § 
    • Acriflavine

    • § 
    • Ethidum aminoglycosides (Kanamycin, treptomycin)

    • § 
    • Fluoroquinolones (ciprofloxacin, daunomycin,
    • doxorubicin, norfloxacin)
  57. OATK-1 is a?
    Methotrexate transporter
  58. OATK-2 transports?
    Taurocholate, methotrexate, folate, prostaglandin E2
  59. Simon is a big?
    Boy

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