tox 2 opiods

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Author:
coal
ID:
243127
Filename:
tox 2 opiods
Updated:
2013-10-27 10:41:39
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tox opiods
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tox 2 opiods
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  1. chemical has the highest percentage of death from overdose
    prescription opiods
  2. 2 chemicals most used in combination of opioid use
    • marijuana
    • alcohol
  3. #1 opioid on the market
    oxycodone - oxycontin
  4. endogenous opioid peptides
    • endorphins
    • enkephalin
    • dynorphins
  5. alter pain pathway
    • Opioid-receptor (OR) activation results in inhibition of adenyl cyclase activity activation of K+ channels Suppression of voltage-gated Ca2+ channels Decreased neurotransmitter release.
    • also inhibits GABA release
  6. four primary classes of opioid receptors
    • mu
    • kappa
    • delta
    • nociceptive
  7. mediates repiratory response
    brainstem
  8. mediates nociception
    • hypothalamus
    • amygdala
    • dorsal-root ganglia
  9. mediates pupillary contracion
    edinger-west nucleus
  10. this drug interferes with opioid metabolism
    phenothiazines
  11. these drugs increase oral bioavailability
    cyclic antidepressants
  12. this drug increases effects of opioids by slowing metabolism
    erythromycin
  13. this drug decrease effects of opioids
    rifampin
  14. classic triad of opioid toxicity
    • CNS depression
    • respiratory depression
    • miosis - pinpoint pupils
  15. what should always be checked if opioid overdose is suspected
    acetaminophen levels
  16. general Tx of opioid overdose
    • airway management and naloxone
    • AC if w/in 1-2 hrs

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