Upper Resp Infection

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  1. Major etiological agents of colds 
    • Rhino-30-50%
    • Corona-25-30%
    • Adeno-5-10%
  2. Piconavirdae virus 
    • ss (+) RNA 
    • naked 
  3. How many serotypes does the piconavirdae virus have?
  4. Which agent is the cause of most common colds?
    Rhino--> Rhinitis 
  5. What is the seq of events for Rhino colds
    • VP1 binds ICAM receptors on host cells 
    • virus spreds as fomites 
  6. What is immunity due to? Last how long?
    • sIgA 
    • lasts 18 months 
  7. Why is it NOT a good candidate for a vaccine
    • Ad drift (major change in viral surf proteins)
    • sIgA response 
    • too many serotypes 
  8. Coronavirus 
    (+) RNA virus 
  9. What does the coronavirus have in it?
    glycoproteins (spike) IN envelope=males it look like a crown 
  10. What is the etiological agent of corona?
    Human Coronavirus (HCoV)
  11. What can the coronavirus cause?
    upper/lower resp tract infections 
  12. What does SARS stand for?
    Severe acute respiratory distress syndrome 
  13. Etiological agent of SARS called what?
  14. SARS signs and symptoms 
    fever, influenza-like, malaise, loss of appetite, myalgia 
  15. What is the new Coronavirus known as?
    London1_new CoV 2012
  16. Adenovirus structure
    Naked ds DNA virus 
  17. How many serotypes of adenovirus? How many can infect human?
    • 100+ serotypes
    • 52 infect humans 
  18. What S&S does adenovirus cause?
    Fever, sore throat, lymphadenopathy 
  19. Influenze structure
    • Orthomyxovirus 
    • ss (-) RNA
  20. How many parts of influenza are there?
    Orthomyxovirus, Hemagglutinin, and Neruaminidase 
  21. How many segments does influenza have?
    • 8 segments 
    • it is also enveloped
  22. How many Hemagglutinin does influenza have?
    16 of them
  23. What is trimeric?
    major surface glycoproteins 
  24. What does trimeric do?
    allows silaic acid residue on cell surface to allow attachment 
  25. What occurs after trimeric attachment? Encoded by what?
    • mediates fusion of endocytosed vision with endosome 
    • Encoded by segment 4 
  26. How many Neuraminidase (N or NA) are there?
    9 segments 
  27. What do neruaminidase do?
    leave silica residues on host cells 
  28. What does the M1 part do?
    • it is the matrix protein
    • promotes assembly 
  29. What does the M2 part FORM?
    forms protein channels in host cell memb
  30. What does the M2 part promote 
    promotes uncoating&viral release
  31. What does the M2 part target?
    Target of amantadine and rimantadine 
  32. What is the NP part?
  33. What did the M1, M2, and NP distinguish?
    influenza A, B, and C 
  34. What is the pathogenesis of Influenza?
    • HA binds siliac acid on host cells 
    • NA cleaves siliac acid residues
    • Virus endocytosed
    • ciliated, epith, mucus-secreting cells die
  35. What is the pathogenesis of the viral infection?
    • causes desqumation of alveloar epithelium 
    • caused by SARS and Influenza
  36. What does the viral infection influe cause?
    • inflammation response 
    • edema and alveolar wall necrosis
  37. What is the time course determined by?
    IFN and T-cell response 
  38. What is the classic flu symptoms due to?
    IFN induction 
  39. What is the incubation period for influenza?
    1-4 days 
  40. How many flu types are there?
    3 (A, B, and C)
  41. Type A is what/affects what?
    • avian 
    • affects mammalian hosts 
  42. A has how many segments/proteins?
    8 segments and 10 proteins 
  43. Type A drift?
    antigenic shift and drift 
  44. Type B 
    affect humans
  45. Type B seg/proteins
    • NO antigenic shift
    • YES antigenic drift 
  46. Type C 
    affects pigs/humans 
  47. Type C seg/proteins
    7 segments and 7 proteins 
  48. Type C shift and drift
    • no antigenic shift
    • yes antigenic drift 
  49. How are viruses classified?
    • types
    • place of original isolation 
    • date of isolation 
    • antigen
  50. What is the antigenic drift?
    repeated mutations cause slow change in hemagglutinin Ags 
  51. What is antigenic shift?
    genomic re-assortmnet cause abrupt, major change in hemagglutinin 
  52. What does the CDC recommend neuraminidase inhibitors 
  53. Why do they recommend it?
    neuraminidase inhibitors block Inf A by inhibiting endosomal acidification 
Card Set:
Upper Resp Infection
2013-10-28 20:32:51

Exam 2
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