Upper Resp Infection
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Major etiological agents of colds
How many serotypes does the piconavirdae virus have?
Which agent is the cause of most common colds?
What is the seq of events for Rhino colds
- VP1 binds ICAM receptors on host cells
- virus spreds as fomites
What is immunity due to? Last how long?
Why is it NOT a good candidate for a vaccine
- Ad drift (major change in viral surf proteins)
- sIgA response
- too many serotypes
(+) RNA virus
What does the coronavirus have in it?
glycoproteins (spike) IN envelope=males it look like a crown
What is the etiological agent of corona?
Human Coronavirus (HCoV)
What can the coronavirus cause?
upper/lower resp tract infections
What does SARS stand for?
Severe acute respiratory distress syndrome
Etiological agent of SARS called what?
SARS signs and symptoms
fever, influenza-like, malaise, loss of appetite, myalgia
What is the new Coronavirus known as?
London1_new CoV 2012
Naked ds DNA virus
How many serotypes of adenovirus? How many can infect human?
- 100+ serotypes
- 52 infect humans
What S&S does adenovirus cause?
Fever, sore throat, lymphadenopathy
- ss (-) RNA
How many parts of influenza are there?
Orthomyxovirus, Hemagglutinin, and Neruaminidase
How many segments does influenza have?
- 8 segments
- it is also enveloped
How many Hemagglutinin does influenza have?
16 of them
What is trimeric?
major surface glycoproteins
What does trimeric do?
allows silaic acid residue on cell surface to allow attachment
What occurs after trimeric attachment? Encoded by what?
- mediates fusion of endocytosed vision with endosome
- Encoded by segment 4
How many Neuraminidase (N or NA) are there?
What do neruaminidase do?
leave silica residues on host cells
What does the M1 part do?
- it is the matrix protein
- promotes assembly
What does the M2 part FORM?
forms protein channels in host cell memb
What does the M2 part promote
promotes uncoating&viral release
What does the M2 part target?
Target of amantadine and rimantadine
What is the NP part?
What did the M1, M2, and NP distinguish?
influenza A, B, and C
What is the pathogenesis of Influenza?
- ENTRY INTO HOST
- HA binds siliac acid on host cells
- NA cleaves siliac acid residues
- Virus endocytosed
- ciliated, epith, mucus-secreting cells die
What is the pathogenesis of the viral infection?
- causes desqumation of alveloar epithelium
- caused by SARS and Influenza
What does the viral infection influe cause?
- inflammation response
- edema and alveolar wall necrosis
What is the time course determined by?
IFN and T-cell response
What is the classic flu symptoms due to?
What is the incubation period for influenza?
How many flu types are there?
3 (A, B, and C)
Type A is what/affects what?
- affects mammalian hosts
A has how many segments/proteins?
8 segments and 10 proteins
Type A drift?
antigenic shift and drift
Type B seg/proteins
- NO antigenic shift
- YES antigenic drift
Type C seg/proteins
7 segments and 7 proteins
Type C shift and drift
- no antigenic shift
- yes antigenic drift
How are viruses classified?
- place of original isolation
- date of isolation
What is the antigenic drift?
repeated mutations cause slow change in hemagglutinin Ags
What is antigenic shift?
genomic re-assortmnet cause abrupt, major change in hemagglutinin
What does the CDC recommend neuraminidase inhibitors
Why do they recommend it?
neuraminidase inhibitors block Inf A by inhibiting endosomal acidification
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