Home > Preview
The flashcards below were created by user
on FreezingBlue Flashcards.
What is Polycythemia Vera?
A myeloproliferative disorder characterized by abnormally increased number of RBCs
- Men Hct >/= 50%
- Women Hct >/= 45%
- - RBC mass study - elevated
- - Erythropoietin level - low/normal
- - Bone marrow biopsy - hypercellular marrow
Polycythemia Vera treatment:
- Serial phlebotomy to Hct <45 in men; <42 women
- Daily Aspirin
- Hydroxyurea for those at high risk of thrombosis
- - age>70, prior thrombosis, platelets>1500000, + CV risk factors
- Anagrelide - decreases platelets in refractory cases
Warfarin therapy INR goals:
1.5-2.0 - older pts with nonvalvular afib or recurrent systemic embolization
2.5-3.5 - pts with mechanical prosthetic valves
Disseminated Intravascular Coagulation
- Platelets - elevated
- PT - elevated
- PTT - elevated
- Fibrinogen - low
- D-dimer - elevated (d/t microvascular clotting)
Causes of DIC:
- Acute leukemia
- Liver disease
Acquired bleeding disorder characterized by low platelets, prolonged coagulation times (esp factors 5, 8, & 13), and low fibrinogen levels
The disease process causes fibrin formation and then breakdown, consuming clotting factors. Fragmentation of RBCs can also occur as they travel through fibrin strands.
What would you like to do?
Home > Flashcards > Print Preview