neurologypharm

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Author:
kjschult
ID:
243711
Filename:
neurologypharm
Updated:
2013-10-29 16:26:08
Tags:
neurologypharm
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Description:
neurology rotation pharm
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  1. Phenytoin (Dilantin)
    • MoA: Incr Na+ activation
    • Used for: Partial seizures
    • SE: Gingival hyperplasia, coarsening of facial features, ataxia
  2. Carbamazapine (Tegretol)
    • MoA: Incr Na activation
    • Used for: Partial seizures
    • SE: Hyponatremia, agranulocytosis, diplopia
  3. Valproic acid (Depakote)
    • MoA: Incr Na channel activation and GABA concentration
    • Used for: Partial and generalized seizures
    • SE: GI sx, tremor, weight gain, hair loss, hepatotoxicity, thrombocytopenia
  4. Phenobarbital
    • MoA: Increases GABAa action
    • Used for: Partial and generalized seizures
    • SE: Sedation
  5. Ethosuximide (Zarontin)
    • MoA: Blocks thalamic T-type Ca2+ channels
    • Used for: Absence seizures
    • SE: GI sx
  6. Gabapentin (Neurontin)
    • MoA: Inhibits HVA Ca channels
    • Used for: Partial seizures
    • SE: Sedation, ataxia
  7. Lamotrigine (Lamictal)
    • MoA: Blocks voltage gated Na channels
    • Used for: Partial and generalized seizures
    • SE: Rash, Steven-Johnson syndrome
  8. Topiramate (Topamax)
    • MoA: Blocks Na channels and incr GAGA action
    • Used for: Partial and generalized seizures
    • SE: Word-finding difficulty, renal stones, weight loss
  9. Tiagabine (Gabitril)
    • MoA: inhibits GABA reuptake
    • Used for: Partial seizures
    • SE: Sedation
  10. Levetiracetam (Keppra)
    • MoA: May modulate GABA and gluamate release
    • Used for: Particial and generalized seizures
    • SE: Insomnia, anxiety, irritability
  11. Oxcarbazepine (Trileptal)
    • MoA: Na channel
    • Used for: Partial seizures
    • SE: Sedation and hyponatremia
  12. Zonisamide (Zonegran)
    • MoA: Unknown
    • Used for: partial and generalized seizures
    • SE: Sedation, renal stones, weight loss

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