Antimicrobial Peptides

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Author:
mame727
ID:
243844
Filename:
Antimicrobial Peptides
Updated:
2013-10-30 00:56:34
Tags:
Peptide location active against
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Description:
Table 6-3 Antimicrobial peptides
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  1. Phpholipases A2 (pla2 most active)
    • Locaiton:
    • Pmn primary granules, Intestinal Paneth cells, Tears, Serum (pits)
    • Active Against:
    • gp and gn bacteria together with bpi
  2. alpha defensins
    • Location:
    • Pmn primary granules and Intestinal Paneth cells

    • Active Against:
    • Bacteria, fungi, some parasites and viruses
  3. beta defensins
    • Location:
    • Induced in epithelial cells (skin, respiratory tract, genitourinary tract)

    • Active Against:
    • Bacteria and fungi
  4. Ribonucleases
    • Location:
    • Consitiutive and induced in epithelial cells (skin, genitourinary tract, intestinal tract)
    • Pmns, monocytes

    • Active Against:
    • Bacteria and fungi
  5. Dermcidin
    Sweat glands

    • Active Against:
    • Bacteria and Fungi
  6. Bpi
    Pmn primary granules

    • Action against:
    • Gram-negative bacteria
  7. Cathelicidins (cap18 in humans)
    • Location:
    • Pmn secondary granules

    • Active against:
    • Bacteria and fungi
  8. Serprocidins (serine proteases: elastase, cathepsin G, proteinase 3)
    • Location:
    • Pmna Primary granules

    • Active Against:
    • Bacteria and fungi
  9. Lysozyme
    • Location:
    • Phagocyte granules
    • Tears, saliva
    • serum
    • Intestinal paneth cells

    • Active Against:
    • Gram-positive bacteria (hydrolyzes peptidoglycan)

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