PHRD5015 Lecture 18 (Ju) - Autoimmunity

The flashcards below were created by user daynuhmay on FreezingBlue Flashcards.

  1. autoimmunity
    unwanted immune response against self-tissue Ags that cause chronic inflammatory injury
  2. 3 genes commonly mutated in autoimmune diseases
    • 1) CTLA4
    • 2) IL-10
    • 3) FasL
  3. molecular mimicry
    • activated T cells clear pathogen during infection, but then recognize something similar
    • in the body that should be recognized as self
  4. chronic, systemic, inflammatory disease that primarily affects synovial membranes of multiple joints in the body
  5. pathogenesis of RA
    • 1) T cell activation by unknown Ag's
    • 2) initiation of inflammatory response
    • 3) cytokine production, synovial inflammation
  6. RA "T cell centric" theory
    • known association of RA w/ MHC II Ag's
    • large # CD4+ T cells in RA synovium
  7. RA Macrophage Theory
    while T cells may be important in initiating disease, chronic inflammation is perpetuated by macrophages and fibroblasts though T cell INDEPENDENT manner
  8. IL-1 fcn in RA
    • secreted by macrophages
    • maintain synovial fibroblast in an activated state
  9. TNFImage Upload fcn in RA
    same as IL-1 fcn -> maintain synovial fibroblast in activated state
  10. GM-CSF fcn in RA
    • secreted by fibroblasts
    • promotes maturation of newly recruited monocytes to macrophages
  11. IL-6 fcn in RA
    • produced by both macrophages & fibroblasts
    • stimulates B cell maturation to plasma cell
  12. IL-8 fcn in RA
    • secreted by fibroblasts
    • recruit neutrophils to site
  13. chronic, inflammatory autoimmune disorder than may affect multiple organ systems
    systemic lupus erythematosus
  14. clinical features NOT typically seen in drug-induced SLE
    • 1) renal
    • 2) vasculitis
    • 3) CNS
  15. autoantigens targeted in SLE (4)
    • 1) ssDNA
    • 2) dsDNA
    • 3) histone
    • 4) chromatins
  16. SLE is what type of hypersensitivity rxn?
    Type III (immune-complex-mediated)
  17. CD4+ T cell mediated inflammatory disease that targets insulin-producing islet Image Upload cells
    insulin dependent diabetes mellitus
  18. T cell-mediated autoimmune disease targeting the myelin sheath surrounding the nerve fibres
    multiple sclerosis
  19. IFN-Image Uploadmechanism of action for MS (4)
    • 1) inhibit leukocyte proliferation
    • 2) inhibit Ag presentation
    • 3) inhibit T-cell migration across BBB
    • 4) modulate cytokine production
  20. natalizumab mech of action for MS
    anti-Image Upload4 integrin mAb binds VLA-4 to mediate CNS migration of lymphocytes
  21. mitoxantrone mech of action for MS (4)
    • 1) DNA crosslinks/breaks; inhibit DNA repair
    • 2) cytocidal effect 
    • 3) inhibits B/T cell & macrophage proliferation 4) impair Ag presentation
  22. glatiramer acetate mech of action for MS
    peptide tetramer (GLATiramer) resembling protein found on myelin that diverts autoimmune response away from myelin
  23. fingolimod mech of action for MS
    downregulates S1P1 expression on activated T cells to decrease gradient -> cells unresponsive & unable to migrate out of lymph nodes -> reduced lymphocytes in CNS
  24. teriflunomide mech of action for MS (2)
    • 1) inhibits pyrimidine synthesis
    • 2) reduces # activated lymphocytes in CNS
  25. laquinimod mech of action for MS (3)
    • 1) small molecule w/ anti-inflammatory properties
    • 2) prevent Tcell infiltration to CNS
    • 3) affect Ag presentation
Card Set:
PHRD5015 Lecture 18 (Ju) - Autoimmunity
2013-10-30 12:31:57
PHRD5015 Autoimmunity

Show Answers: