Saliva function/drugs

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Author:
Aleksbaron
ID:
243889
Filename:
Saliva function/drugs
Updated:
2013-10-30 08:50:02
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OBIO Exam
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OBIO Exam 2
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  1. Name the 3 antisialogoges
    Propantheline

    Methantheline

    Glycopyrrolate
  2. What are some side effects of antisialogoges?
    Tachycardia, droosiness, decreased intestinal or bladder smooth muscle action
  3. Name 2 sialogoges? (parasympathomimetics)
    Bethanecol

    Cevimeline

    Pilocarpine
  4. Contraindications of sialogoges (muscarinic agonists)?
    Asthma and complete loss of salivary gland
  5. Unstimulated whole saliva flow range?
    0.1-0.5 ml/min

    parotid 25%, SM/SL 63%
  6. Stimulated saliva flow range?
    1.1-3.0 ml/min

    with acid 60% secreted by parotid comapred to only 25% unstimulated
  7. Cranial innervation from VII (7) to which glands?
    Submand/Subling
  8. Cranial innervation IX (9) to which glands?
    Parotid gland through otic ganglion

    from Superior and inferior nuclei of brainstem
  9. What do mucins do?
    provide viscosity, pellicle component, binding site for bacteria

    large, hydrophilic, hydrated molecules
  10. What do lactoferrins do?
    binds iron, inhibits bacterial growth
  11. What do lysozymes do?
    antimicrobial, acts on cell wall
  12. What do histatins do?
    histidine rich peptides

    POWERFUL ANTIFUNGALS
  13. What do lactoperoxidases do?
    forms hypothiocyanite ion, highly toxic to bacteria
  14. What does amylase do?
    hydrolyzes starch, helps clear carbohydrate from, may be antimicrobial
  15. What do statherin's do?
    tyrosine rich peptide

    inhibits spontaneous CaPO4 precipitation, remineralizaiton of small lesions
  16. What to proline-rich proteins do ?
    70% of protein make-up of saliva

    bind tannins, control calculus
  17. What is the only negative inhibition for saliva production?
    Fear-hypothalamus
  18. What ions are reabsorbed to make saliva hypotonic in collecting ducts?
    Na+, Cl-

    K+ and HCO3- are not reabsorbed
  19. What percent of acinar is storage of granules?
    30% of cytoplasm
  20. What are the Calcium dependent channels, their location?
    Potassium is basolateral

    Chloride is apical
  21. How do we get potassium in during resting?
    SPCC

    Na/K ATPase (sodium 2 out and 3 K in)
  22. Recall the movement of ions in HCO3 dependent saliva secretion.
  23. Steps to ion transport when acinar cell is stimulated.

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