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Name the 3 antisialogoges
What are some side effects of antisialogoges?
Tachycardia, droosiness, decreased intestinal or bladder smooth muscle action
Name 2 sialogoges? (parasympathomimetics)
Contraindications of sialogoges (muscarinic agonists)?
Asthma and complete loss of salivary gland
Unstimulated whole saliva flow range?
parotid 25%, SM/SL 63%
Stimulated saliva flow range?
with acid 60% secreted by parotid comapred to only 25% unstimulated
Cranial innervation from VII (7) to which glands?
Cranial innervation IX (9) to which glands?
Parotid gland through otic ganglion
from Superior and inferior nuclei of brainstem
What do mucins do?
provide viscosity, pellicle component, binding site for bacteria
large, hydrophilic, hydrated molecules
What do lactoferrins do?
binds iron, inhibits bacterial growth
What do lysozymes do?
antimicrobial, acts on cell wall
What do histatins do?
histidine rich peptides
What do lactoperoxidases do?
forms hypothiocyanite ion, highly toxic to bacteria
What does amylase do?
hydrolyzes starch, helps clear carbohydrate from, may be antimicrobial
What do statherin's do?
tyrosine rich peptide
inhibits spontaneous CaPO4 precipitation, remineralizaiton of small lesions
What to proline-rich proteins do ?
70% of protein make-up of saliva
bind tannins, control calculus
What is the only negative inhibition for saliva production?
What ions are reabsorbed to make saliva hypotonic in collecting ducts?
K+ and HCO3- are not reabsorbed
What percent of acinar is storage of granules?
30% of cytoplasm
What are the Calcium dependent channels, their location?
Potassium is basolateral
Chloride is apical
How do we get potassium in during resting?
Na/K ATPase (sodium 2 out and 3 K in)
Recall the movement of ions in HCO3 dependent saliva secretion.
Steps to ion transport when acinar cell is stimulated.