Bacterial toxins page 1

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  1. Bacillus antracis
     (anthrax toxin, paeflf)
    Disrupts cell signaling, cell migration, and cell death.

    • cell binding domain
    •       Facilitates the entry of either edema factor        or lethal factor.

    • Edema (swelling)
    •        Calmodulin-dependent adenylate cyclase
    •        ; increases cAmp in target cells. This                results in localized edema.

    • Pulmonary edema; anti-phagocytic
    •         Zinc-dependent protease that cleaves a           host signal transduction molecule.
  2. Bordetella pertussis (apt)
    Adelylate cyclase toxin
    Pertussis toxin
    Tracheal cytotoxin
    • Antiphagocytic, inhibits and kills leukocytes.
    •      Calmodulin-activated adenylate cyclase            causes an increase in target cell cAmp              levels and a decrease in atp production.            This modifies cell function, resulting in the          death of the cell.
    • Many hormonal effects
    •         Adp ribosylation of signal transducing G           protein blocks signal transduction.
    • Kills cilia-bearing cells.
  3. Campylobacter jejuni
    • Diarrhea
    •      Adp ribosylation of signal transducing G proteins, blocks signal transduction.
  4. Clostridium botulinum
    Botulin (neurotoxin)
    • Flaccid paralysis
    •     Cleavage of neuromuscular presynaptic proteins blocks presynaptic junctions. This results in the decreased release of acetylcholine.
  5. Clostridium difficile
    • Hemorrhagic diarrhea
    •     Acts at the membrane.

    Cells lose filaments
  6. Clostridium species
     alpha toxin
     beta toxin
    • Necrosis in gas gangrene; cytolytic; lethal
    •     Phospholipase c
    • Necrotic enteritis
    • Food poisoning; diarrhea
    •    Cytotoxin; damages membranes.
  7. Clostridium tetani
    tetanospasmin (neurotoxin)
    • spastic (rigid) paralysis
    •    cleavage of synaptobrevin prevents the release of gamma-aminobutyric acid and glycine from the synapses of inhibitory neurons.
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Bacterial toxins page 1
Bacterial toxins
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