Bacterial Toxins page 2

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mame727
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244290
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Bacterial Toxins page 2
Updated:
2013-11-01 03:23:08
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Page bacterial toxins
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Bacterial Toxins page 2
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  1. Corynebacterium diptheriae
    Diphtheria toxin
    • cytolysis (cell death); kills cells
    •    Adp ribosylation of elongation factor 2 results in the inhibition of protein synthesis.
  2. Escherichia coli
    Heat-labile enterotoxin
    cytotoxin
    Heat-stable enterotoxin
    • Diarrhea
    •        Identical to cholera toxin
    • Hemorrhagic colitis
    •        Identical in action to shiga toxin- adp ribosylation of adenylate cyclase results in its activation. this results in an increase in camp levels in a cell.
    • Diarrhea
    •        Activates host guanylate cyclase
  3. Legionella pneumophila
      cytotoxin
    cytlysis (cell death); lyses cells
  4. Listeria monocytogenes
       Listeriolysin
    • lyses cells
    •     Membrane damage; similar in action to               streptolysin O.
  5. Pseudomonas aeruginosa
    Exotoxin A
    Type 3 cytotoxins
    • cytolysis (cell death); kills cells
    •         Similar in action to diptheria toxin
    •         Adp ribosylation of elongation factor 2 results in the inhibition of protein synthesis.
    • Modulate host cell physiology
    •          Inhibits actin cytoskeleton
  6. Salmonella enterica serovars
    type 3 cytotoxin
    • Modulate host cell physiology
    •     Alters actin cytoskeleton.
  7. Shigella dysenteriae
    shiga toxin (enterotoxin)
    • cytolysis (cell death); kills cells
    •   Inactivates 60s ribosome, thereby preventing protein synthesis.
  8. Staphylococcus aureus
    alpha
    beta
    gamma
    toxic shock syndrome toxin
    exfoliative toxin
    • Hemolytic, leukocytic, paralysis of smooth muscle
    •      Pore-forming toxin
    • cytolytis (cell death)
    •      sphingomyelinase
    • cytolysis
    •    detergent-like action
    • Food poisoning: emesis, diarrhea
    •      super antigen: activate host antibody and        cytokine synthesis by an antigen                      independent action.
    • Slouphing of skin, associated with scladed skin syndrome
    •       super antigen: protease
  9. Streptococcus pneumonia
    pneumolysin
    • cytolysis
    •    Similar to streptolysin O- pore fore forming (membrane damage)
  10. Streptococcus pyogenes
    Streptolysin O
    Erythrogenic toxin
    • Cytolysis
    •        Pore-forming toxin
    • Fevern neutropenia, rash associated with scarlet fever
  11. Vibrio cholera
    choleragen (enterotoxin)
    • Diarrhea (secretory diarrhea)
    •         Adp ribosylation of adenylate cyclase results in its activation. This results in an increase in cAmp levels in a cell.
  12. Yersinia enterocolitica
    Heat-stable enterotoxin
    Type three cytoxins
    • Diarrhea
    •     Activate host guanylate cyclase

    • Modulate host cell physiology
    •       Regulate cytoskeleton

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