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What happens in immunosuppression?
What are the several methods of immunosuppression used?
The pathogen inhibits or suppresses either specific or non-specific immune responses.
- Impair the function of lymphoid and myeloid cells-
- measles virus, hepatitis B virus and influenza virus (hiv 1 and hiv 2)
- Destroy leukocytes
- Interfere with cytokines and interferons
- Target antigen presentation (removal of mhc by adenovirus)
What is evasion of the phagocyte function?
What are examples of phagocytes?
Phagocyte migration, phagocytosis, and antigen presentation.
Macrophages, Neutrophils, and Dendritic cells.
What are the several ways that pathogens can avoid phagocytic death?
- Kill phagocytes
- Avoid being killed by phagocytes
- Persist within phagocytes
What happens in the evasion of phagocyte function of kiling phagocytes?
How do leukocidins of then work?
What organisms use killing phagocytes (leukocidins)?
Production of leucocidins: proteins that are toxic to white blood cells/ leukocytes.
They work at a distance to kill the phagocyte before it comes near to the pathogen.
Staphylococcus, streptococcus, and pseudomonas.