Ch 6 Notes Pt. 2

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DesLee26
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Ch 6 Notes Pt. 2
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2013-11-02 18:29:23
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CHM 201
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  1. What does second order depend on? What don't second order reactions do?

    What do all elimination reactions form?
    • concentration of two species
    • do not compete with first order reactions

    alkenes
  2. What do you need if new bonds are formed?

    What do first order reactions have?
    a leaving group

    intermediates
  3. In substitutions,  our base is a __ or a __. 
    - the rate of the reaction is dependent upon __.

    Second-order reactions have __.
    • Lewis base or nucleophile
    • concentration of electrophile and nucleophile

    no intermediates
  4. A leaving group must be on __. If there's too much __, there may not be a __.
    • the sp3 center
    • steric tension
    • leaving group
  5. As you go down a period table, __ increases, __ decreases.
    • nucleophilicity
    • basicity
  6. Elimination wants a __. SN2 wants __. 

    What is one of the best nucleophiles?
    • strong base
    • a sufficient one
    • Iodine
  7. If you use a strong base, you run the risk of __.
    deprotonating
  8. Leaving groups can what?
    OTs= __
    • be kicked out of the molecule
    • tosylate is a good leaving group; if you see it, its leaving
  9. Elimination reactions produce what?

    E2 is __.

    What are the conditions of E2?

    What does it do to the electron?
    • more products
    • one step
    • similar
    • pluck off
  10. How would we be able to determine a substraet?
    look at the size and nature of the base and nature of the substrate
  11. What is the alpha position? Beta position?

    If you have a hydrogen that is __ to the _, they must be __ apart.
    • alpha position is the carbon bearing the leaving group
    • beta group is the position adjacent to the leaving group
    • anti
    • leaving group
    • 180 degrees
  12. Nucleophile behaves as a __, which __, kicks out the __, and forms a __.
    • Bronsted- Lowry base
    • deprotonates
    • leaving group
    • pi bond
  13. Primary alkyl halides typically undergo __, regardless of the strength. May produce __ and __ products.
    • elimination
    • major and min problems
  14. High temperatures favor __.

    Stereochemistry of E2: In a Fischer projection, the groups on the same side are both __. Do we want that? What do w do?
    • elimination
    • eclipsed
    • no
    • redraw
  15. What are some good bases?
    • NaOH
    • NaOCH3
    • NaOCH2CH3
    • KOC(CH3)3
    • NaNR2
  16. E2 reactions have a specific orientation= must be __. __ will determine the product. 

    When looking at the conformation and seeing wedges and dashes, what will occur?
    • anti
    • reactive conformation

    wedges will be on the same side and dashes will be on the same side, in terms of top and bottom
  17. Leaving groups on rings?

    Which position is least reactive? What must be done?
    one must be straight up, the other=straight down

    • equatorial
    • you must flip the chair conformation to make it axial
  18. What must simple cyclos do? How do you achieve this?
    adopt an unstable position; heating up the reactant will allow more equilibrium to occur, thus leading to an increased amount of unstable products
  19. Zaitsev's rule?
    the alkene that prevails is the most highly subbed; more than one alkene product will be formed
  20. Hyperconjugation?
    the more associations with neighboring bonds, the lower energy it is
  21. When trying to determine which beta hydrogen will react in a ring, what do you have to do?

    What are the only H's that can move?
    make a chair conformation

    the ones that are anti (axial) to the other
  22. Even if a double bond is a more stable bond, if it does not have a beta hydrogen in an anti-axial position, what can't it do?
    it cant react
  23. In SN1 and E1, what do you want?

    What is it called?

    What do they do more than the Sn2 reactions?

    SN1 and E1 work well on what? 

    What is the rate reaction?
    a solvent with a pair of electrons, not a strong nucleophile or base

    solvolysis

    compete more

    tertiary reactions

    first order
  24. What do SN1 and E1 form?
    a polar intermediate= carbocations, which have the same stabilities as free radicals 3>2>1>CH3X
  25. What do you do to the first order reactions?

    - In ___, it dissociates. 

    What determines it?
    warm up in excess solvent

    polar protic solvents

    whether or not you can access the carbocation (the more highly subbed, the more accessible)
  26. First order rate reactions form?
    form intermediate and take to product

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