MMI 302 Lecture 12: Host-Microbe Interactions

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  1. Host to Microbial Division
    • 8/10 veterbrate organ systems appear to have coevolved with microbes 
    • 1:10 cells (1013 host cells:1014 bacterial cells)
    • 1:1 gene number (Hosts have 30,000 per cell, microbes 3,000)
    • 1:200 gene diversity
  2. Systems in which Microbiota has effect:
    Immune, Circulatory, Digestive, Neuroendocrine, Excretory, Musculoskeletal, integumentary, adipose
  3. Steps of Horizontally Acquired Symbiosis
    Establishment, Development, Stability
  4. Establishment
    Microbiota acquired at birth (usually from parent)
  5. Development
    Microbiota changes throughout childhood to better function with the changing organ systems, ecological succession occurs.
  6. Stability
    Sustained partner exchange, homeostatis resilience/robustness
  7. Pathogenesis represents what in terms of the normal microbiota
    • An imbalance
    • Intrinsic forces are imbalances caused by genetics
    • Extrinsic forces are imbalances caused by abiotic (antibiotics, pollutants, hormones) and biotic (invasive species can be or not be coevoleved)
  8. Simple experimental models
    Hydras, Medicinal leech, Bobtail squid, Zebrafish
  9. Hydra are used to study
  10. Which species colonize a hydra depends on
  11. Hydra's epithelium is full of:
    Antimicrobial peptides
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MMI 302 Lecture 12: Host-Microbe Interactions
2013-11-04 15:59:18
MMI 302

MMI 302
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