Biochem 501: Lecture 27: Synthesis of Ketones, Sterols and Isoprenoids

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Ketogenesis
- Occurs in liver
- Keto bodies are alternate fuel source
Physiological Conditions that Promote Ketogenesis
- Fasting/starvation
- Diabetes
- Ketogenic diet
- -High fat
- -Newborn
- All occur during low insulin
Ketone bodies
- Acetoacetate
- beta-hydroxybutyrate
- -circulating fuels produced by liver, non-glucose foods during fasting
- Acetone
Use of Ketone bodies
- Produced in liverUsed by heart muscle/kidney
- Starvation: brain
- Excess Ac-CoA - low OAA in TCA
- Diabetics: acetone breath
Ketone body formation and export from the liver
Liver can do what with Acetyl-CoA

When low insulin/high beta oxydation, A-CoA exceeds Oxaloacetate, this means there are leftover A-CoA

Author:	Anonymous
ID:	245549
Card Set:	Biochem 501: Lecture 27: Synthesis of Ketones, Sterols and Isoprenoids
Updated:	2013-11-07 01:49:31
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Description:	Biochem 501
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