Biochem 501: Lecture 27: Synthesis of Ketones, Sterols and Isoprenoids

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Biochem 501: Lecture 27: Synthesis of Ketones, Sterols and Isoprenoids
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2013-11-06 20:49:31
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Biochem 501
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Biochem 501
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  1. Ketogenesis
    • Occurs in liver
    • Keto bodies are alternate fuel source
  2. Physiological Conditions that Promote Ketogenesis
    • Fasting/starvation
    • Diabetes
    • Ketogenic diet
    • -High fat
    • -Newborn
    • All occur during low insulin
  3. Ketone bodies
    • Acetoacetate
    • beta-hydroxybutyrate
    •      -circulating fuels produced by liver,                    non-glucose foods during fasting
    • Acetone
  4. Use of Ketone bodies
    • Produced in liverUsed by heart muscle/kidney
    • Starvation: brain
    • Excess Ac-CoA - low OAA in TCA
    • Diabetics:  acetone breath
  5. Ketone body formation and export from the liver
  6. Liver can do what with Acetyl-CoA
    When low insulin/high beta oxydation, A-CoA exceeds Oxaloacetate, this means there are leftover A-CoA

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