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describe the broad process of the heart formation
one tube, than 2 tubes that fuses to become a four chambered tube with septa and valves
what is the prevalence of heart anomalies caused by embryo defects
.7-.8 % (1%)
what are the two leading cause of death in the neonatal phase^
- 1. prematurity
- 2. congenital heart disease
tell me about the nkx2 gene
- - knock out = no heart (tin man gene)
- - fundamental for heart dev.
4 diseases connected to genetic mutation leading in heart development defect
trisomie 21 (down's), tris. 18 (edwards), turners, tris 22 (digeorge)
environmental factors for heart malformation in embryo
measles, diabetes, rubella, vit A disturbances
what happened on day 14 of heart formation
tell me more about hemangioblast-epithelia
- - mother or all blood cells
- - mesodermal region
- - begins gastrulation
in embryo, what day the first heart beat
what is "ready" by day 21 of the heart dev.
- the two endocardial tubes have folded in pericardial cavity
- whole network of vessels developed
- first heartbeat
- heart begins pumping
what are the two folds of the endocardial tube
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