dmrn108

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Author:
blkbunny20
ID:
24570
Filename:
dmrn108
Updated:
2010-06-27 15:06:24
Tags:
antibiotic immune sys
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Description:
antimicrobial immune system
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  1. antibiotic
    chemical produced by one microbe that can harm another microbe
  2. antimicrobial
    any agent that can harm microbes
  3. bacteriocidal drug
    drugs that kill microbes
  4. bacteriostatic drug
    drugs that slow microbe production
  5. chemotherapy
    using chemical against invading organisms
  6. selective toxicity
    no injury to cell host only target organism
  7. narrow spectrum antibiotics
    work only on a few microbes
  8. broad specturm antibiotics
    active against a wide variety of microbes
  9. nosocomial infection
    infection acquired at hospital
  10. 2 ways resistance acquired
    • spontaneous mutation
    • conjugation
  11. suprainfection
    new infection appears during course of treatment for a primary infection
  12. minimum inhibitory concentration
    lowest concentration of antibiotic that produces complete inhibition of bacterial growth
  13. minimum bacteriocidal concentration
    lowest concentration of drug that kills 99.9% bacterial colonies
  14. kerniterus
    sever neurologic disorder caused by displaced billirubin from protein plasma
  15. level of antibiotic at site of infection
    4-8 times the MIC
  16. beta lactam
    antibiotic that destroy beta lactam ring or wall of bacteria
  17. penicillin G
    • bet-lactem
    • ADR
    • allergies
  18. cephalexin (keflex)
    • beta-lactam
    • ADR
    • bleeding
    • allergies
    • INTER
    • disulfiram
    • probenecid
  19. Imipenem (primaxin)
    • beta-lactam
    • ADR
    • allergies
    • gastroinstestinal
    • suprainfection
  20. vancomycin (vancocin)
    • red man syndrome
    • ototoxicity
    • infusion reaction
  21. tetracycline hydrochloride (sumycin)
    • Gastrointestinal
    • tooth discoloration
    • suprainfection
    • INTER
    • oral contriceptives
    • Milk calcium iron magnesium supplements
  22. Erythromycin (E-mycin)
    • bacteriostatic
    • ADR
    • gastrointestinal
    • thrombophlebitis
    • INTER
    • antihystamines
    • theophyline
    • warfarin
    • carbamazepine
  23. Gentamycin (garamycin)
    • ototoxicity
    • nephrotoxicity
    • neuromuscular blockage
  24. trimethoprim-sulfamethoxazole (TMP-SMZ)
    bactrim
    • folic acid
    • stevens-johnson
    • blood dyscrasias
    • crystalluria
    • kernicterus
  25. nitrofurantoin (macrodantin)
    • bacteriostatic low dose
    • bacteriocidal high dose
    • ADR
    • GI
    • blood dyscrasias
  26. isoniazid (INH)
    • antituberculosis drug
    • neuropathy
    • hepatotoxicity
    • INTER
    • phenytoin
    • alcohol
  27. dapsone (leprosy)
    anti-hansens disease
    • folic acid
    • ADR
    • hepatotoxicity
    • GI
    • INTER
    • warfarin
    • oral contraceptive
    • NNRTI for HIV
  28. acyclovir (zovirax)
    • prevents DNA reproduction
    • ADR
    • phlebitis
    • nephrotoxicity
    • INTER
    • granulocytopenia
    • thrombocytopenia
    • reproductive toxocity
  29. ciprofloxacin (cipro)
    • stop dna replication
    • ADR
    • GI
    • achillies tendon rupture
    • suprainfection
    • INTER
    • warfarin
    • theophyline
    • milk iron mg dairy
  30. metronidazole (flagyl)
    • bacteriocidal anaerobic
    • ADR
    • metallic taste
    • dark urine
    • cns symptoms
    • INTER
    • alochol
    • disulfiram
    • warfarin
  31. amphoterin B deoxycholate
    (fungizone)
    • antifungal
    • ADR
    • infusion reaction
    • nephrotoxicity
    • hypokalemia
    • bone marrow suppresion
  32. ketoconazole (nizarol)
    • hepatotoxicity
    • ADR
    • gynecomastia
    • irregular menstral flow
    • INTER
    • flucytosine
    • aminoglycosides
  33. B cells
    produce antibodies
  34. Immunosuppressants
    • reduce production of B cells and
    • cytotoxic T cells CD8
  35. immunostimulant
    • boost the immune system
    • assist body to kill cancer cells
  36. macrophages and dendritic cells
    phagocytosis
  37. cytolytic T lymphocytes
    (CD8)
    destroy target cells directly and killing microbe
  38. Helper T cells (CD4)
    • activate B cells
    • delayed hypersensitivity reaction (DTH)
  39. Natural Immunity
    innate-native immunity
    present at birth
  40. specific acquired immunity
    a persons body produce antibodies to protect itself
  41. active acquired immunity
    • having the infoection
    • admin of vaccine or toxoid
  42. passive acquired immunity
    • admin of preformed antibodies
    • immunoglobulins
  43. acquired immunity (2)
    • active by vaccinations
    • passive by immunoglobulins
  44. alt name for antibodies
    • immunoglobulins
    • gamma globulins
  45. 5 classes of antibodies
    • IgA
    • IgD
    • IgE
    • IgG
    • IgM
  46. antigen
    molecules that trigger specific immune response and become targets if those responses
  47. toxoid vacccine
    DTaP vaccine
  48. live vaccines
    • MMR
    • Varicella
    • Influenza
    • Rotavirus
  49. guillain- barre syndrome
    • autoimmune disorder of peripheral nervous system
    • caused by flu vaccine
  50. MMR
    • local reaction
    • ADR
    • allergy to eggs gelatin neomycin
  51. Dtap
    • encephalopathy 7 days after
    • seizure
  52. reyes syndrome
    aspirin to kids
  53. tetanus booster
    every 10 years
  54. Interferon alfa (interleukin-2)
    • stop cancer cells
    • ADR
    • alopecia
    • bone marrow suppresion
    • cardiotoxicity
    • neurotoxicity
    • hypotension
    • INTER
  55. cyclosporine
    • hepatotoxic
    • nephrotoxicity
    • grapefruit juice
  56. prednisone
    • glucocorticoids
    • ADR
    • bone loss
    • adrenal impariment
    • fluid retention
    • INTER
    • diuretic
    • NSAIDs
  57. azathioprine
    • cytotoxic drug
    • bone marrow depression
    • allopurinol
  58. antihistamine
    1st generation
    • dephenhydramine (benadryl)
    • dimenhydrinate (dramimine)
  59. antihistamine
    2nd generation
    • loratadine (claritin)
    • fexofenadine (allegra)
    • cetirizine (zyrtec)
  60. chemotherapy agents
    anticancer agents to kill cancer cells
  61. antitumor antibiotics
    doxorubicin (adrimycin)
  62. breast cancer antibiotic
    antiestrogen (tamoxifen)
  63. prostate cancer antibiotic
    leuprolide (lupron)
  64. chemotherapy side effects
    • alopecia
    • bone marrow suppression
    • GI discomfort give antiemetic
    • extravasation of vesicants
  65. antihistamine
    (h1 antagonist)
  66. neuroleptic malignant syndrome
    • fever
    • muscular rigidity
    • autonomic dysfunction
    • altered mental status
  67. steven-johnson syndrome
    epidermis detaches from dermis

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