pharm 4 allergy drugs

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Author:
kbryant86
ID:
245899
Filename:
pharm 4 allergy drugs
Updated:
2013-11-08 17:11:30
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pharm 4
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  1. Diphenhydramine / Benadryl
    -peropheral and CNS effects
    • 1st gen antihistamine
    • -H1 antagonist
    • -blocks histamine reseptors

    PE= reduce flushing, edema, musoucs secretion, itching

    • CNS= sedation
    • **IN high doses--> CNS stimulation and seizures b/c histamine blocks seizure activity
  2. Loratidine / Claritin
    -pns and cns effects
    • 2nd gen antihistamine
    • -blocks receptors

    pe= same as benadryl

    cns= very little, is long acting
  3. Azelastine / Astelin
    • 2nd gen antihist
    • Nasal spray
    • blocks hist receps

    drowsiness and throat irritation
  4. COX 1
    • cyclooxgenase (product of arach. acid production)
    • the Good Cox
    • -In ALL tissues

    • protects against mucosa-increasing blood flow
    • supports renal function
    • promotes platelet aggregation
  5. inhibition of COX 1
    • gastric erosion
    • renal impairment
    • bleeding
    • prevent MI/stroke
  6. COX 2
    • Bad COX
    • at site of injury
    • mediates inflammation
    • sensitizes pain receptors
    • mediates fever and pain in brain
    • supports renal function
    • vasodilation
    • promotes colon cancer
  7. inhibition of COX 2
    decrease pain, fever inflamm

    • promote renal failure
    • promote embolic events (MI)
  8. ASA and NSAIDS
    • COX inhibitor
    • Stop production of prostaglandins
    • -suppress inflamm
    • -relieve pain
    • -reduce fever

    • risk of:
    • stomach ulcer
    • bleeding
    • renal impairment
  9. ASA
    • Aspirin
    • NON-selective COX inhibitor
    • Irreversible

    • Suppress inflamm, analgesia, and platelets. Reduce fever, relief of dysmenorrhea, colorectal cancer preventtion, Alz's prevention
    • Stroke and MI protection

    SE: GI, bleed, RI, Reye's, ringing in ears
  10. NSAID's
    • Ibuprofen, Naproxan - po forms
    • 1st gen COX 1 & 2 inhibitors
    • Reversible

    rheumatoid and osteoarthritis pain relief

    SE: blding, GI, renal impairment, slight inc. in thrombotic events
  11. Ketorolak / Toradol
    • IV/IM version of NSAID
    • -relieves surgical pain as well as opioid
  12. Celecoxib / Celebrex
    2nd gen COX 2 inhibitor

    • reduce pain, fever, and inflammation
    • -W/O bleeding, renal failure, and GI problems associated with COX 1 inhibition
  13. Acetaminophen
    2nd most used drug in US

    • Anti-pyretic and analgesic effects
    • -No inflamm effects
    • -Inhibits prostaglandin synthesis in CNS only

    inhibits metabolism of Warfarin
  14. Acetylcystine / Mucomyst
    Antidote for Acetaminophen overdose

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