Biochemical mechanisms of LTP
LTPs are regulated by _______ which is _______. Normally the NMDA channel is blocked by _________ and only the AMPA channel functions. With ________ activation of AMPA receptors, __________ drives _____ out of the NMDA receptor and ______ can enter.
The rapid _______ of ____ ions triggers processes that lead to LTP. Once this occurs, activation of _______ ________ changes the structure of the postsynaptic membrane, allowing for LTP and an increase in ________ ________. A LTP can also result from changes in the presynaptic _____ release. Retrograde messengers, such as ______ ______ are sent from the postsynaptic to presynaptic membrane to increase ______ ______
- protein kinases
- synaptic reactivity
- nitric oxide
- NT release
Although LTP is important in memory formation, it's most probably not the only player in learning