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What is the 2 component of proton-motive force?
Chemical potential energy and Electrical potential energy
Chemical Potential Energy
Due to the difference in concentration of a chemical species (H+) separated by a membrane
Electrical Potential Energy
Results from a separation of charge across a membrane
2 basic postulates of Chemiosmotic model
- 1. electrons flow through transport chain, Energy released create proton gradient across inner mitochon membrane
- 2. protons move back across inner mitochon membrane release E that drive syntheses of ATP.
Venturicidin or oligomycin
Inhibitors of ATP synthase
Uncoupler, membrane soluble weak acid.
Can be synthesis in the absence of an oxidizable substrate, proton-motive force is sufficient to drive ATP synthesis
Complex V. proton-translocating multisubunit, transmembrane protein.
What are the 2 functional domain of ATP synthase?
- F0: integral to membrane
- F1: peripheral to the membrane
ATP synthase F1 complex
Each of the 3 beta subunit has one catalytic site for the ATP
ATP synthase F0
Make up the proton pore and is composed of subunit ab2c10-12
What are the 2 specific systems that transport ADP and P into the mitochon matrix and ATP out to cytosol
- 1. Adenine nucleotide translocase
- 2. Phosphate translocase
Primarily used by heart, kidney and liver. 2.5 ATP generated by pair of electrons that are passed from NADH to O2
Glycerol 3-Phosphate shuttle
Used by skeletal muscle and brain.
How many ATP does G-3-P shuttle provide
1.5 ATP molecule per pairs of electrons.
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