Types of Signals

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Author:
DesLee26
ID:
246243
Filename:
Types of Signals
Updated:
2013-11-10 22:09:49
Tags:
Cell Bio
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Mickle
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  1. Signal peptide
    -which protein?
    -location?
    -function?
    -How?
    • - secretory proteins
    • - N-terminus
    • - destines it to the ER
    • - polypeptide moves through cotranslationally
  2. Retrieval signal: KDEL
    -which protein?
    -location?
    -function?
    -How?
    • -proteins that normally reside in the ER
    • -at the C-terminus
    • -tells receptors that they belong in the ER and helps them return them back to here
    • -capturing and returning them back into COPI-coated vesicles
  3. Retrieval signal
    -which protein?
    -location?
    -function?
    -How?
    • -for ER membrane proteins
    • -involves two closely-linked basic residues, most commonly KKXX
    • - n/a
    • - n/a
  4. mannose-6-phosphate signal
    -which protein?
    -location?
    -function?
    -How?
    • -lysosomal enzymes
    • -on lysosomal enzymes
    • -recognized by M6P receptors, which enable capturing and concentration into clathrin-coated vesicles
    • -n/a
  5. Peroxisomal targeting sequence
    -which protein?
    -function?
    • -peroxisome-destined proteins
    • -PTS receptors bind to them
  6. Stroma targeting domain
    -which protein?
    -location?
    -function?
    -How?
    • -chloroplast destined cells
    • -transit peptide
    • - guarantees that the polypeptide will enter the stroma and then is cleaved by a processing peptidase
  7. thylakoid transfer domain
    -which protein?
    -location?
    • -polypeptides destined to go to a thylakoid membrane or lumen
    • -transit peptide
  8. removable targeting sequence on mitochondrial protein
    -location?
    - n terminus
  9. Explain the ssynthesis of a polypeptide
    mRNA binds to ribosomeà ribosome begins translating that sequence of bases into amino acid sequences--> signal peptide is synthesized on N-terminusà signal recognition particle binds to it and the ribosomeà translation stopsà SRP guides the complex to a SRP receptorà two sorts of interactions: SRP to SRP receptor and ribosome to transloconà SRP is releasedà translation continues as the polypeptide is being translated through the pore
  10. O

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