Other Structures

Card Set Information

Author:
DesLee26
ID:
246244
Filename:
Other Structures
Updated:
2013-11-11 13:12:27
Tags:
Cell Bio
Folders:

Description:
Mickle
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user DesLee26 on FreezingBlue Flashcards. What would you like to do?


  1. Signal Recognition particle
    - structure
    • Six distinct polypeptides and one RNA molecule= 7S
    • GTP protein (as well as its receptor)
  2. Signal Recognition particle
    - function
    Binds to both ribosome and signal sequence and guides it to an SRP receptor, which will then enable the ribosome to bind to the translocon
  3. Translocon
    -structure
    • Protein lined channel embedded in the ER membrane
    • Integral membrane proteins
    • thought to have a lateral gate that opens and closes to allow for single-spanning polypeptides to obtain the proper orientation based on solubility
  4. Translocon
    -function
    • Allows passage of polypeptide from the ribosome into the ER
    • In inactive state: plugged by a short alpha helix
    • If dealing with a multispanning segment, it can properly orient its transmembrane segments
  5. Translocon
    -location
    on the cytosolic side of the RER
  6. Oligosaccharyltransferases
    -structure
    integral membrane protien
  7. Oligosaccharyltransferases
    -function
    adds oligosaccharides to teh polypeptide in the ER
  8. Signal peptidase
    - funciton
    cleave off hte signal peptide from the new polypeptide
  9. ER chaperones
    -function
    bind to unfolded or misfolded proteins and give htem a chance to fold correctly
  10. PDI (protein disulfide isomerase)
    -function
    • forms and rearranges the disulfide bonds on new polypeptides that were originally cysteine residues in their inactive state
    • -processing enzyme
  11. glycosyltransferase
    -function
    Adds sugars to oligosaccharide chains; transfers from a nucleotide sugar to the growing end of the carb chain
  12. Dolichol phosphate
    -function
    • Lipid carrier¬† in which the basal segment of each carb chain is assembled on
    • These then get transferred to asparagines residues by oligosaccharyltransferase¬†
  13. Dolichol phosphate
    -location
    embedded int he ER membrane by a lipid anchor
  14. Glucosidase II
    -function
    Removes any remaining glucose after the gradual modification when two of the three glucose molecules were removed
  15. UGGT
    -function
    Conformation-sensing enzyme that recognizes a misfolded or incompletely folded glycoprotein and ads a single glucose residue back to one of the mannose residues; allows rhe ER chaperone to recognize it
  16. BiP
    -structure
    molecular chaperone
  17. BiP
    -function
    keeps the sensors that detect misfolded proteins in an inactive state
  18. Sialyltransferase
    -function
    • Adds sialic acid to the terminal position of the chain
  19. Sialyltransferase
    -location
    in the trans face of the Golgi
  20. Sar1
    -structure
    GTP protein
  21. Sar1
    -function
    • When activated, it inserts its N-terminal into the lipid bilayer, causing bending
    • Also plays a regulatory role
    • Initiates vesicle formation and regulates assembly of the vesicle coat
  22. KDEL receptor
    -structure
    integral membrane protein
  23. KDEL receptor
    -function
    Shuttles between the cis Golgi and ER compartments, recognizing and returning proteins of the ER
  24. GGAs
    -structure
    • Contain several domains, each capable of grasping a different protein involved in vesicle formation
  25. GGAs
    -function
    • Outer ends bind to clathrin, holding the clathrin scaffolding onto the surface of the vesicles
  26. Arf1
    -structure
    GTP-binding protein
  27. Arf1
    -function
    • Sets the stage for the binding of other coat proteins to clathrin-coated vesicles
    • It extends a membrane-bending alpha helix that acts in conjunction with the clathrin coat to initiate budding of the vesicle
  28. Rab
    -structure
    G proteins that bind to membranes by a lipid anchor
  29. Rab
    -function
    Membrane trafficking and vesicle targeting; also deals with recruiting proteins involved in membrane trafficking like motor proteins
  30. SNAREs
    -structure
    • Contains a SNARE motif that allows binding to other SNARE motifs on other membranes
    • v-snares: become incorporated into membranes of transport vesicles during budding
    • t-snares: located in membranes of target compartments
  31. SNAREs
    -function
    Proteins that engage in the docking interactions, where the cytosolic regions of integral proteins of two membranes interact

What would you like to do?

Home > Flashcards > Print Preview