Vesicles and Complexes

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Author:
DesLee26
ID:
246248
Filename:
Vesicles and Complexes
Updated:
2013-11-10 23:10:54
Tags:
Cell Bio
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Mickle
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  1. COPII
    -function
    • Mediate first leg of the biosynthetic pathway
    • Select and concentrate certain components for transport as long as they have an ER export signal as part of their cytosolic tail
    • -          Binds proteins that will function in later stages in the pathway, help docking and fusion, or can bind soluble particles
  2. COPII
    -Structure
    Contains a small Gprotein called Sar1, which plays a regulatory role by initiating vesicle formation and regulating the assembly of the vesicle coat
  3. COPI
    - function
    • Function in the retrograde transport of proteins , such as transà cis or ERGIC à ER
    • -          retaining or retrieval
  4. COPI
    - structure
    • Contains a membrane bending protein called Arf1
  5. TOM Complex
    -functoin
    Contains receptors that recognize and bind mitochondrial proteins and protein-lined channels through which unfolded polypeptides are translocated across the outer membrane
  6. TOM complex
    -location
    OMM
  7. TIM complexes
    -location
    IMM
  8. TIM complex 22
    -function
    Binds integral proteins of the IMM that contain an internal targeting sequence and inserts them into the lipid bilayer
  9. TIM complex 23
    -function
    Binds proteins with an N-terminal presequence, which includes all of the proteins of the matrix; it recognizes and translocates the matrix proteins completely through the IMM and into the inner aqueous compartment

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