What are the two "types" (re: association with receptor) of kinases, and how do they function?
- Receptor kinases: (covalent) one protein has receptor and kinase
- Upon ligand binding the receptor/kinase protein dimerizes.autophosphorylates
- Non-receptor kinases: (noncovalent) two proteins
- 1. The kinase and receptor are noncovalently associated at the membrane and dimerize/autophosphorylate after ligand binding
- 2. The kinase is associated with a membrane protein unassociated with the receptor. The two are only brought together after ligand binds to the receptor by co-receptors
- *note- this is most important to lymphocyte receptors