Antiviral agents

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Author:
ucstudent01
ID:
247107
Filename:
Antiviral agents
Updated:
2013-11-15 19:37:37
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Antiviral agents
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antiviral agents
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  1. Nucleoside analogues do what to prevent growth (mechanism)
    May inhibit: nucleoside inhibitor:

    • DNA or RNA polymerase
    • Reverse transcriptase
  2. Acyclovir & valacyclovir (is pro)

    Mechanism
    Used for what
    gauanine analogue

    HSV & VZV

    Not for CMV
  3. Ganciclovir

    Mechanism
    Used for what
    guanine analogue

    CMV (works for all herpes, just more toxic)
  4. Vidarabine is used for what
    NOTHING!

    OLD antiviral drug
  5. Ribavirin

    Mechanism
    Used for what
    • Inhibits replication of:
    • Influenza A & B
    • RSV
  6. Foscarnet

    mechanism
    resistance
    *Direct inhibitor of DNA polymerase & RT

    HSV,VZV,CMV

    drug resistance to others

    affects kidneys
  7. Azidothymidine - zidovudine

    Mechanism
    • RT inhibitor
    • Anti- retrovirus agent

    Cellular enzyme phosphorylate to the triphosphate form which inhibits RT and causes chain termination
  8. RT Inhiboitors that are NON- nucleoside inhibitors
    Neviparine,delaviridine,efavirenz

    Noncompetitive binding to RT and direct inhibition at a different from AZT
  9. Protease Inhibitors

    Mechinism
    resistance
    saquinavir,ritonavir,indinavir,nelfinavir

    protease competitively Inhibits maturation of virions 

    HIV-1 - need prolonged use
  10. Amanatadine
    Prevents uncoating or assembly

    **rimantadine - less CNS toxicity
  11. Neurominidase inhibitor
    Function as a neuraminidase inhibitor - Prevents budding vuruses from cell

    zanamivir, tamiflu, 

    Flue A & B and H5N1 (avian)

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