Q: what is the effect of food on pharmacokinetics and pharmacodynamics?
A: compared to fasting, Dexilant increase Cmax range from 12%-55%, and increases AUC range from 9%-37%, and Tmax varied ranging from .7-3 hours. No mean difference in intragistric pH. Intragistric pH exceeded 4 over 24-hour dosing interval decrease slightly when Dexilant was administered after a meal 57% relative to fasting 64% primary due to a decrease response in intragastric pH during the first 4 hours after dosing. So, DEXilant can be takend without regard to food.