Neuro Final Exam

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248534
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Neuro Final Exam
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2013-11-22 15:09:12
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Neuro Final Exam
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  1. Amitriptyline (Elavil)
    • Tertiary tricyclic amine 
    • Inhibition of monoamine (NE, 5-HT, DA) reuptake transporters (SERT>NET>DAT)
    • M1/M3 muscarinic cholinergic antagonism
    • CNS H1 histamine antagonism
    • a1 adrenergic antagonism
  2. Nortriptyline (Pamelor)
    • Secondary tricyclic amine- demethylated product of Amitriptyline, longer half life
    • Inhibition of monoamine (NE, 5-HT, DA) reuptake transporters (NET>SERT>DAT)
    • M1/M3 muscarinic cholinergic antagonism
    • CNS H1 histamine antagonism
    • a1 adrenergic antagonism
  3. Amoxapine (Ascendin®)
    Tricyclic amine and a D2 dopamine receptor antagonist used for treatment ofdepressed patients with psychosis; may cause some breast enlargement and galactorrhea (because dopamine inhibits prolactin secretion)
  4. Phenelzine (Nardil®)
    Irreversible, non-selective MAOI
  5. Deprenyl (Selegiline®)
    • Selective MAO-B inhibitors
    • Boosts brain dopamine levels (MAO-B oxidizes DA with greater selectivity)
  6. Moclobemide (Aurorix®)
    Reversible, non-selective MAOI

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