MMI 301: Lecture 20: Pseudomonas

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MMI 301: Lecture 20: Pseudomonas
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2013-11-22 17:08:47
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MMI 301
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  1. Pseudomonas are classic example of:
    Opportunistic pathogen
  2. Pseudomonas morphology
    • Gram - rod
    • facultative anaerobe
    • non-fermentative
  3. Pseudomonas can be found
    • Throughout the enviroment, contacted almost every day
    • SUPER UBIQUITOUS
  4. Ways Pseudomonas can become pathogenic
    • Break in physical barriers
    •    -wound, injection
    •    -serious underlying disease: burns, leukemia, cystic fibrosis
  5. P. aeruginosa structure
    Motile by polar flagella, type IV pili
  6. Pseudomonas aeruginosa energy
    • Technically a facultative anaerobe
    • Does not ferment
    • Mistaken as aerobe
    • Readily grows on most lab media
  7. Pseudomonas metabolics
    • Derive energy and carbon from a wide range of organic compounds
    • Can grow at a relatively wide range of temperatures (4-42 degrees C)
  8. Pseudomonas produce:
    • Diffusible pigments
    • Produce green halos from blue (pyocyanin) and yellow (fluorescein) pigments
    • Pigments will fluoresce with long wave-length UV lamp. Burn wound infected with Pseudomonas can glow
  9. Pseudomonas aeruginosa smells like
    Grapes
  10. Genetically engineered Pseudomonas was given patent
    cleaned oil spills
  11. Pseudomonas aeruginosa use QS
  12. Pseudomonas aeruginosa in CF patients
    • Often produce lots of extracellular polysaccharides made of alginate
    • gives mucoid appearance
  13. Important exopolysaccharides in infection Pseudomonas aeruginosa
    alginate and PsI
  14. Pseudomonas aeruginosa virulence genes
    • Adhesive type IV pili
    • Tip of the flagellum has a cap protein that binds mucin
    • Produces multiple toxins with the most notable bing exotoxin A
    • Produces elastases LasA/B
    •      -Degrades tissue proteins, tissue destruction and degrading of antimicrobial peptide LL-37
    • Two hemolysins
    • Pyocyanin pigment catalyzes superoxide and peroxide production and oxidative damage
  15. Pseudomonas aeruginosa genes needed for virulence
    • phzB: pyocyanin
    • mexA: efflux pump
    • hrpM: biofilm formation

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