"Ketoconazole is characterized by having a low solubility and a high permeability. This has shown to cause problems with drug release and there have been numerous efforts to resolve this issue."
Why is knowing this important to you?
- Doctor... Can I ask you a question?
- Your a podiatrist or dermatologist or family practitioner so you probably prescribe a fair amount of ketoconazole, would you agree?
- Yah, I write for it a fair amount
Well doctor I just read that ketoconazole has a very poor solubility. In fact so much so that there have been numerous efforts to solve the issue. YTD they have not. Do you have any patients that require multiple rounds of oral anti fungal therapy?
It is those patients that bring me to your office today. Doctor we have a new excipient that has been studied with the API ketoconazole. It has shown to increase solubility and dispersibility in the gut, therefore increasing bio-availability.
Now Nizoral has MCC in it which only hinders the bioavailability even more, by prolonging the release of the drug.
Our new compound base LoxOral not only aids in the dispersion and solubility of the Ketoconazole in the gut, but it is the only Ketoconazole oral preparation that complies with USP dissolution specification. It states in the USP "the dissolution specification for Ketoconazole is not to be less than 80% of the labeled amount of the drug"
Our compounded formulation is 80.78%
- So doctor. Would you be willing to try this on a few patients to see if we can optimize their outcome?
Role play with your boss, your techs whatever. This is what drug reps do and like it or not those drug reps are entering the world of compounding. They are professionally trained sales people. So everyone is going to have to up their game. If you can answer every question in this test correctly you will be able to have the conversation above off the cuff. Also it will bleed over into other areas.